Liver-specific microRNA-122 Biogenesis and function

被引：329

作者：

Jopling, Catherine L. ^{[1
]}

机构：

[1] Univ Nottingham, Ctr Biomol Sci, Nottingham NG7 2RD, England

来源：

RNA BIOLOGY | 2012年 / 9卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

MicroRNA; miR-122; Pri-miRNA; GLD-2; CAT-1; Cholesterol; Hepatitis C virus; C VIRUS TRANSLATION; MIR-122; EXPRESSION; 3' ADENYLATION; SMALL RNAS; IN-VIVO; IDENTIFICATION; STABILITY; GENOME; GENES;

D O I：

10.4161/rna.18827

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

microRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.

引用

页码：137 / 142

页数：6

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