Microwave-assisted cyclocondensation of hydrazine derivatives with alkyl dihalides or ditosylates in aqueous media: syntheses of pyrazole, pyrazolidine and phthalazine derivatives

被引：65

作者：

Ju, YH ^{[1
]}

Varma, RS ^{[1
]}

机构：

[1] US EPA, Natl Risk Managment Res Lab, Clean Proc Branch, Sustainable Technol Div, Cincinnati, OH 45268 USA

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 36期

关键词：

cyclocondensation; microwave irradiation; heterocycles; 4,5-dihydro-pyrazole; 1,2-dihydro-phthalazine;

D O I：

10.1016/j.tetlet.2005.07.018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct syntheses of 4,5-dihydro-pyrazole, pyrazolidine, and 1,2-dihydro-phthalazine derivatives via double-alkylation of hydrazines by alkyl dihalides or ditosylates were accomplished in aqueous media under microwave irradiation conditions; the environmentally friendlier chemical transformation occurred in a single step and eliminated the use of expensive metal catalysts in building two C-N bonds. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：6011 / 6014

页数：4

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