Prevalence of the T215Y mutation in human immunodeficiency virus type 1-infected pregnant women in a New York cohort, 1995-1999

被引：5

作者：

Sitnitskaya, Y ^{[1
]}

Rochford, G ^{[1
]}

Rigaud, M ^{[1
]}

Essajee, S ^{[1
]}

Pollack, H ^{[1
]}

Krasinski, K ^{[1
]}

Borkowsky, W ^{[1
]}

机构：

[1] NYU, Sch Med, Div Pediat Infect Dis, New York, NY 10016 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2001年 / 33卷 / 01期

关键词：

D O I：

10.1086/320877

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

From 1997 through 1999, the prevalence of the zidovudine resistance mutation T215Y was 9.7% among pregnant women, and the human immunodeficiency virus type 1 (HIV-1) load in those with resistant virus was higher than that measured in women with wild-type HIV-1. All mutations were noted in women with zidovudine experience, which suggests that monotherapy may not be adequate prophylaxis for vertical transmission of HIV-1 infection in the current era.

引用

页码：E3 / E7

页数：5

共 34 条

[1]

[Anonymous], 1998, MMWR Recomm Rep, V47, P1

[2] HIV-1 drug resistance in newly infected individuals [J].

Boden, D ;

Hurley, A ;

Zhang, LQ ;

Cao, YZ ;

Guo, Y ;

Jones, E ;

Tsay, J ;

Ip, J ;

Farthing, C ;

Limoli, K ;

Parkin, N ;

Markowitz, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (12) :1135-1141

[3] Selective vertical transmission of HIV-1 antiretroviral resistance mutations [J].

Colgrove, RC ;

Pitt, J ;

Chung, PH ;

Welles, SL ;

Japour, AJ .

AIDS, 1998, 12 (17) :2281-2288

[4] First case of new infection with zidovudine-resistant HIV-1 among prospectively studied intravenous drug users and homosexual men in Amsterdam, The Netherlands [J].

deRonde, A ;

Schuurman, R ;

Goudsmit, J ;

vandenHoek, A ;

Boucher, C .

AIDS, 1996, 10 (02) :231-232

[5] Maternal viral genotypic zidovudine resistance and infrequent failure of zidovudine therapy to prevent perinatal transmission of human immunodeficiency virus type 1 in Pediatric AIDS Clinical Trials Group protocol 076 [J].

Eastman, PS ;

Shapiro, DE ;

Coombs, RW ;

Frenkel, LM ;

McSherry, GD ;

Britto, P ;

Herman, SA ;

Sperling, RS .

JOURNAL OF INFECTIOUS DISEASES, 1998, 177 (03) :557-564

[6] EFFECTS OF ZIDOVUDINE USE DURING PREGNANCY ON RESISTANCE AND VERTICAL TRANSMISSION OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 [J].

FRENKEL, LM ;

WAGNER, LE ;

DEMETER, LM ;

DEWHURST, S ;

COOMBS, RW ;

MURANTE, BL ;

REICHMAN, RC .

CLINICAL INFECTIOUS DISEASES, 1995, 20 (05) :1321-1326

[7] Prevalence of genotypic resistance to nucleoside analogues in antiretroviral-naive and antiretroviral-experienced HIV-infected patients in Spain [J].

Gomez-Cano, M ;

Rubio, A ;

Puig, T ;

Perez-Olmeda, M ;

Ruiz, L ;

Soriano, V ;

Pineda, JA ;

Zamora, L ;

Xaus, N ;

Clotet, E ;

Leal, M .

AIDS, 1998, 12 (09) :1015-1020

[8] Patterns of resistance mutations selected by treatment of human immunodeficiency virus type 1 infection with zidovudine, didanosine, and nevirapine [J].

Hanna, GJ ;

Johnson, VA ;

Kuritzkes, DR ;

Richman, DD ;

Brown, AJL ;

Savara, AV ;

Hazelwood, JD ;

D'Aquila, RT .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) :904-911

[9] Primary infection with zidovudine-resistant human immunodeficiency virus type 1 does not adversely affect outcome at 1 year [J].

Imrie, A ;

Carr, A ;

Duncombe, C ;

Finlayson, R ;

Vizzard, J ;

Law, M ;

Kaldor, J ;

Penny, R ;

Cooper, DA .

JOURNAL OF INFECTIOUS DISEASES, 1996, 174 (01) :195-198

[10] PREVALENCE AND CLINICAL-SIGNIFICANCE OF ZIDOVUDINE RESISTANCE MUTATIONS IN HUMAN-IMMUNODEFICIENCY-VIRUS ISOLATED FROM PATIENTS AFTER LONG-TERM ZIDOVUDINE TREATMENT [J].

JAPOUR, AJ ;

WELLES, S ;

DAQUILA, RT ;

JOHNSON, VA ;

RICHMAN, DD ;

COOMBS, RW ;

REICHELDERFER, PS ;

KAHN, JO ;

CRUMPACKER, CS ;

KURITZKES, DR .

JOURNAL OF INFECTIOUS DISEASES, 1995, 171 (05) :1172-1179

← 1 2 3 4 →