Tumor progression: Defining the soil round the tumor seed

被引:108
作者
McCawley, LJ [1 ]
Matrisian, LM [1 ]
机构
[1] Vanderbilt Univ, Dept Canc Biol, Nashville, TN 37232 USA
关键词
D O I
10.1016/S0960-9822(00)00038-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The tumor microenvironment, or stroma, is known to contribute to tumor progression. Two recent studies have shown that the stromal protein matrix metalloproteinase MMp-9 has a role in the early stages of tumor growth and angiogenesis.
引用
收藏
页码:R25 / R27
页数:3
相关论文
共 19 条
[1]   Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis [J].
Bergers, G ;
Brekken, R ;
McMahon, G ;
Vu, TH ;
Itoh, T ;
Tamaki, K ;
Tanzawa, K ;
Thorpe, P ;
Itohara, S ;
Werb, Z ;
Hanahan, D .
NATURE CELL BIOLOGY, 2000, 2 (10) :737-744
[2]   Effects of angiogenesis inhibitors on multistage carcinogenesis in mice [J].
Bergers, G ;
Javaherian, K ;
Lo, KM ;
Folkman, J ;
Hanahan, D .
SCIENCE, 1999, 284 (5415) :808-812
[3]   Extracellular matrix signaling: integration of form and function in normal and malignant cells [J].
Boudreau, N ;
Bissell, MJ .
CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (05) :640-646
[4]   Clinical studies with matrix metalloproteinase inhibitors [J].
Brown, PD .
APMIS, 1999, 107 (01) :174-180
[5]   Changing views of the role of matrix metalloproteinases in metastasis [J].
Chambers, AF ;
Matrisian, LM .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1997, 89 (17) :1260-1270
[6]   Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis [J].
Coussens, LM ;
Raymond, WW ;
Bergers, G ;
Laig-Webster, M ;
Behrendtsen, O ;
Werb, Z ;
Caughey, GH ;
Hanahan, D .
GENES & DEVELOPMENT, 1999, 13 (11) :1382-1397
[7]   MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis [J].
Coussens, LM ;
Tinkle, CL ;
Hanahan, D ;
Werb, Z .
CELL, 2000, 103 (03) :481-490
[8]   MULTISTAGE CARCINOGENESIS IN MOUSE SKIN [J].
DIGIOVANNI, J .
PHARMACOLOGY & THERAPEUTICS, 1992, 54 (01) :63-128
[9]   MODULATION OF THE ORGAN MICROENVIRONMENT FOR TREATMENT OF CANCER METASTASIS [J].
FIDLER, IJ .
JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (21) :1588-1592
[10]  
FIELDING J, 2000, P AN M AM SOC CLIN, V19, pA240