Membrane-bound tyrosine aminopeptidase activities in the rat brain throughout the estrous cycle

被引：4

作者：

deGandarias, JM ^{[1
]}

Irazusta, J ^{[1
]}

Fernandez, D ^{[1
]}

Gallego, M ^{[1
]}

Silio, M ^{[1
]}

Casis, L ^{[1
]}

机构：

[1] UNIV BASQUE COUNTRY,DEPT PHYSIOL,SCH MED,BILBAO,SPAIN

来源：

LIFE SCIENCES | 1996年 / 59卷 / 13期

关键词：

aminopeptidase M; enkephalin metabolism; amygdala; puromycin; estrous cycle;

D O I：

10.1016/0024-3205(96)00424-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Puromycin sensitive and insensitive membrane-bound aminopeptidase activity levels during the estrous cycle in several brain areas have been described in this research. We have found the highest aminopeptidase M activity levels during the proetrous stage in the hypothalamus, the amygdala and the pituitary gland. Since this enzyme has been involved in opioid peptide metabolism, it is suggested that aminopeptidase M could play a part in the decrease in the inhibitory influence of the endogenous opioids peptides that participate in the LH surge.

引用

页码：1097 / 1101

页数：5

共 24 条

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[2]

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[3]

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