A novel access to 2,4-substituted quinolines from acetylenic ketones

被引：25

作者：

Masquelin, T ^{[1
]}

Obrecht, D ^{[1
]}

机构：

[1] F HOFFMANN LA ROCHE & CO LTD,PHARMA RES,CH-4070 BASEL,SWITZERLAND

来源：

TETRAHEDRON | 1997年 / 53卷 / 02期

关键词：

D O I：

10.1016/S0040-4020(96)01025-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2, 4-Substituted quinolines of type 7 and 8 were synthesized starting from 2-amino thiophenol and acetylenic acetals 5 to yield various substituted benzo[b][1, 4] thiazepine intermediates of type 6. Subsequent sulfur extrusion in refluxing toluene led to 2, 4-substituted quinoline acetals 7, which were transformed into the corresponding 2-substituted quinoline-4-carbaldehydes 8 in good to excellent yields. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：641 / 646

页数：6

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