Generating 'tiger' as an animal name or a word beginning with T: Differences in brain activation

被引:264
作者
Mummery, CJ
Patterson, K
Hodges, JR
Wise, RJS
机构
[1] MRC, APPL PSYCHOL UNIT, CAMBRIDGE, ENGLAND
[2] UNIV CAMBRIDGE, NEUROL UNIT, CAMBRIDGE CB2 1TN, ENGLAND
基金
英国惠康基金;
关键词
D O I
10.1098/rspb.1996.0146
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Positron emission tomography was used to investigate differences in regional cerebral activity during word retrieval in response to different prompts. The contrast of semantic category fluency and initial letter fluency resulted in selective activation of left temporal regions; the reverse contrast yielded activation in left frontal regions (BA44/6). A further comparison between types of category fluency demonstrated a more anterior temporal response for natural kinds and more posterior activation for manipulable manmade objects. These results support behavioural data suggesting that category fluency is relatively more dependent on temporal-lobe regions, and initial letter fluency on frontal structures; and that categorical word retrieval is not a uniformly distributed function within the brain. This is compatible with the category-specific deficits observed after some focal lesions.
引用
收藏
页码:989 / 995
页数:7
相关论文
共 27 条
[1]  
ALEXANDER MP, 1989, ARCH NEUROL-CHICAGO, V36, P211
[2]   THE ANATOMY OF PHONOLOGICAL AND SEMANTIC PROCESSING IN NORMAL SUBJECTS [J].
DEMONET, JF ;
CHOLLET, F ;
RAMSAY, S ;
CARDEBAT, D ;
NESPOULOUS, JL ;
WISE, R ;
RASCOL, A ;
FRACKOWIAK, R .
BRAIN, 1992, 115 :1753-1768
[3]   A COMPUTATIONAL MODEL OF SEMANTIC MEMORY IMPAIRMENT - MODALITY SPECIFICITY AND EMERGENT CATEGORY SPECIFICITY [J].
FARAH, MJ ;
MCCLELLAND, JL .
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL, 1991, 120 (04) :339-357
[4]  
FOX PT, 1989, J NUCL MED, V30, P141
[5]  
Friston Holmes, 1994, Human Brain Mapping, V2, P189, DOI [10.1002/hbm.460020402, DOI 10.1002/HBM.460020402]
[6]   A PET STUDY OF WORD FINDING [J].
FRITH, CD ;
FRISTON, KJ ;
LIDDLE, PF ;
FRACKOWIAK, RSJ .
NEUROPSYCHOLOGIA, 1991, 29 (12) :1137-1148
[7]  
GAFFAN D, 1994, EXP BRAIN RES, V99, P411
[8]   NEUROANATOMICAL CORRELATES OF CATEGORY-SPECIFIC SEMANTIC DISORDERS - A CRITICAL SURVEY [J].
GAINOTTI, G ;
SILVERI, MC ;
DANIELE, A ;
GIUSTOLISI, L .
MEMORY, 1995, 3 (3-4) :247-+
[9]   CATEGORY-SPECIFIC NAMING AND COMPREHENSION IMPAIRMENT - A DOUBLE DISSOCIATION [J].
HILLIS, AE ;
CARAMAZZA, A .
BRAIN, 1991, 114 :2081-2094
[10]   IS SEMANTIC MEMORY CONSISTENTLY IMPAIRED EARLY IN THE COURSE OF ALZHEIMERS-DISEASE - NEUROANATOMICAL AND DIAGNOSTIC IMPLICATIONS [J].
HODGES, JR ;
PATTERSON, K .
NEUROPSYCHOLOGIA, 1995, 33 (04) :441-459