Chemical and Pharmacological Studies on Enantiomerically Pure p-Methoxytacripyrines, Promising Multi-Target-Directed Ligands for the Treatment of Alzheimer's Disease

被引：27

作者：

Bartolini, Manuela ^{[1
]}

Pistolozzi, Marco ^{[1
]}

Andrisano, Vincenza ^{[1
]}

Egea, Javier ^{[2
,3
,4
]}

Lopez, Manuela G. ^{[2
,3
,4
]}

Iriepa, Isabel ^{[5
]}

Moraleda, Ignacio ^{[5
]}

Galvez, Enrique ^{[5
]}

Marco-Contelles, Jose ^{[6
]}

Samadi, Abdelouahid ^{[6
]}

机构：

[1] Univ Bologna, Dept Pharmaceut Sci, I-40126 Bologna, Italy

[2] Inst Teofilo Hernando, Madrid 28029, Spain

[3] Univ Autonoma Madrid, Dept Farmacol & Terapeut, Madrid 28029, Spain

[4] Univ Autonoma Madrid, Sch Med, Inst Invest Hosp Univ La Paz IdiPAZ, HIV Unit, Madrid 28046, Spain

[5] Univ Alcala, Dept Quim Organ, Madrid 28871, Spain

[6] CSIC, Lab Radicales Libres & Quim Computac, IQOG, E-28006 Madrid, Spain

来源：

CHEMMEDCHEM | 2011年 / 6卷 / 11期

关键词：

Alzheimer's disease; amyloid beta-peptides; chiral resolution; multi-target-directed ligands; tacripyrine enantiomers; BETA-AMYLOID AGGREGATION; TACRINE-DIHYDROPYRIDINE HYBRIDS; ACETYLCHOLINESTERASE INHIBITORS; DUAL INHIBITORS; PERIPHERAL SITE; BINDING-SITE; PEPTIDE; DESIGN; BUTYRYLCHOLINESTERASE; CHOLINESTERASES;

D O I：

10.1002/cmdc.201100239

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

[No abstract available]

引用

收藏

页码：1990 / 1997

页数：8

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