The non-peptide neuroprotective agent SR 57746A interacts with neurotrophin-3 to induce differentiation in the PC12 cell-line

被引：9

作者：

Fournier, J ^{[1
]}

Boutot, G ^{[1
]}

Keane, PE ^{[1
]}

Maffrand, JP ^{[1
]}

Le Fur, G ^{[1
]}

Soubrié, P ^{[1
]}

机构：

[1] Sanofi Rech, F-31036 Toulouse, France

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1998年 / 50卷 / 03期

关键词：

D O I：

10.1111/j.2042-7158.1998.tb06868.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

SR 57746A (1-(2 beta-naphthylethyl)-4-(3-trifluoromethylphenyl) -1,2,5,6- tetrahydropyridine hydrochloride) is a neuroprotective compound which potentiates nerve-growth factor (NGF)-induced differentiation in PC12 cells. We have evaluated the interaction of SR 57746A with the other members of the neurotrophin family in this cell-line. In contrast with NGF, neurotrophin-3 did not increase the differentiation of PC12 cells. However, the association of SR 57746A with neurotrophin-3 significantly increased neurite outgrowth. No significant activity on neurite outgrowth was observed with brain-derived neurotrophic factor or neurotrophin-4, either alone or combined with SR 57746A. These results indicate that as well as potentiating the effect of NGF SR 57746A enables neurotrophin-3, which alone is inactive, to increase the differentiation of these cells.

引用

页码：323 / 327

页数：5

共 19 条

[1] DIFFERENTIAL EXPRESSION OF NERVE GROWTH-FACTOR RECEPTORS LEADS TO ALTERED BINDING-AFFINITY AND NEUROTROPHIN RESPONSIVENESS [J].