Local application of basic fibroblast growth factor into the bone increases bone mass at the applied site in rabbits

被引：18

作者：

Nakamura, K ^{[1
]}

Kurokawa, T ^{[1
]}

Kato, T ^{[1
]}

Okazaki, H ^{[1
]}

Mamada, K ^{[1
]}

Hanada, K ^{[1
]}

Hiyama, Y ^{[1
]}

Aoyama, I ^{[1
]}

Nakamura, T ^{[1
]}

Tamura, M ^{[1
]}

机构：

[1] KAKEN PHARMACEUT CO LTD,YAMASHIMA KU,KYOTO 607,JAPAN

来源：

ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY | 1996年 / 115卷 / 06期

关键词：

D O I：

10.1007/BF00420329

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

The effect of basic fibroblast growth factor (bFGF) applied locally into the bone under physiological conditions was investigated. An aqueous solution containing O mu g (vehicle), 100 mu g or 400 mu g recombinant human bFGF was percutaneously applied through a needle into the right ilium in rabbit, and the ilia were harvested 4 weeks after the application. Compared with vehicle-treated animals, bone mineral density measured by dual-energy X-ray increased in the 400 mu g bFGF group. The width of trabeculae in the bFGF-treated groups was greater than in the vehicle group. These results showed that bFGF applied locally into the bone under physiological conditions affected bone formation, and suggested that such an application might have potential for increasing bone.

引用

页码：344 / 346

页数：3

共 10 条

[1]

BAYLINK DJ, 1993, J BONE MINER RES, V8, P5565

[2]

BOLANDER ME, 1992, P SOC EXP BIOL MED, V200, P165

[3] EFFECTS OF BASIC FIBROBLAST GROWTH-FACTOR ON BONE-FORMATION INVITRO [J].