Targeted drug delivery to tumors: Myths, reality and possibility

被引:1396
作者
Bae, You Han
Park, Kinam [1 ]
机构
[1] Univ Utah, Coll Pharm, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT 84108 USA
关键词
CANCER STEM-CELLS; BLOCK-COPOLYMER MICELLES; IN-VITRO; VASCULAR-PERMEABILITY; PROTEIN; SIZE; NANOPARTICLES; TRANSPORT; NEOCARZINOSTATIN; HETEROGENEITY;
D O I
10.1016/j.jconrel.2011.06.001
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:198 / 205
页数:8
相关论文
共 91 条
[1]   Is tumor growth sustained by rare cancer stem cells or dominant clones? [J].
Adams, Jerry M. ;
Strasser, Andreas .
CANCER RESEARCH, 2008, 68 (11) :4018-4021
[2]   Drug targeting and tumor heterogeneity [J].
Bae, You Han .
JOURNAL OF CONTROLLED RELEASE, 2009, 133 (01) :2-3
[3]   HEPATIC CIRCULATION - POTENTIAL FOR THERAPEUTIC INTERVENTION [J].
BALLET, F .
PHARMACOLOGY & THERAPEUTICS, 1990, 47 (02) :281-328
[4]   Silica particles:: A novel drug-delivery system [J].
Barbé, C ;
Bartlett, J ;
Kong, LG ;
Finnie, K ;
Lin, HQ ;
Larkin, M ;
Calleja, S ;
Bush, A ;
Calleja, G .
ADVANCED MATERIALS, 2004, 16 (21) :1959-1966
[5]   Chemo-embolization of experimental liver metastases.: Part I:: distribution of biodegradable microspheres of different sizes in an animal model for the locoregional therapy [J].
Bastian, P ;
Bartkowski, R ;
Köhler, H ;
Kissel, T .
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1998, 46 (03) :243-254
[6]   Design of targeted lipid nanocapsules by conjugation of whole antibodies and antibody Fab' fragments [J].
Beduneau, Arnaud ;
Saulnier, Patrick ;
Hindre, Francois ;
Clavreul, Anne ;
Leroux, Jean-Christophe ;
Benoit, Jean-Pierre .
BIOMATERIALS, 2007, 28 (33) :4978-4990
[7]  
Birner P, 2001, CLIN CANCER RES, V7, P1669
[8]   Development of copolymers of poly(D,L-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel [J].
Burt, HM ;
Zhang, XC ;
Toleikis, P ;
Embree, L ;
Hunter, WL .
COLLOIDS AND SURFACES B-BIOINTERFACES, 1999, 16 (1-4) :161-171
[9]   Relevance of folic acid/polymer ratio in targeted PEG-epirubicin conjugates [J].
Canal, Fabiana ;
Vicent, Maria J. ;
Pasut, Gianfranco ;
Schiavon, Oddone .
JOURNAL OF CONTROLLED RELEASE, 2010, 146 (03) :388-399
[10]  
CAPONE PM, 1984, JNCI-J NATL CANCER I, V72, P673