Novel 3-dodecanoylindole-2-carboxylic acid inhibitors of cytosolic phospholipase A2

被引：15

作者：

Lehr, M ^{[1
]}

Klimt, M ^{[1
]}

Elfringhoff, AS ^{[1
]}

机构：

[1] Univ Munster, Inst Pharmaceut Chem, D-48149 Munster, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(01)00472-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Derivatives of 1-[2-(4-carboxyphenoxy)ethyl]-3-dodecanoylindole-2-carboxylic acid (4) with modified substituents at the indole-1-position were synthesized and evaluated for their ability to inhibit the arachidonic acid release in human platelets mediated by the cytosolic phospholipase A(2). One of the most active compounds obtained was 26 with an IC50 of 0.44 muM. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2569 / 2572

页数：4

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