Exploring the role of cancer stem cells in radioresistance

被引：659

作者：

Baumann, Michael ^{[1
,2
]}

Krause, Mechthild

Hill, Richard ^{[3
]}

机构：

[1] Univ Canc Ctr, Fac Med, D-01307 Dresden, Germany

[2] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, D-01307 Dresden, Germany

[3] Univ Toronto, Dept Med Biophys, Princess Margaret Hosp, Ontario Canc Inst, Toronto, ON M5G 2M9, Canada

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 07期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrc2419

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Radiobiological research over the past decades has provided evidence that cancer stem cell content and the intrinsic radiosensitivity of cancer stem cells varies between tumours, thereby affecting their radiocurability. Translation of this knowledge into predictive tests for the clinic has so far been hampered by the lack of methods to discriminate between stem cells and non-stem cells. New technologies allow isolation of cells expressing specific surface markers that are differentially expressed in tumour cell subpopulations that are enriched for cancer stem cells. Combining these techniques with functional radiobiological assays holds the potential to elucidate the role of cancer stem cells in radioresistance in individual tumours, and to use this knowledge for the development of predictive markers for optimization of radiotherapy.

引用

收藏

页码：545 / 554

页数：11

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