Correlation of Cyr61 and CTGF in placentas from the late pre-eclamptic pregnancy

被引：15

作者：

Chen, Xi ^{[1
]}

Liu, Yanyan ^{[1
]}

Xu, Xiaoyan ^{[1
]}

Chen, Hanping ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan 430074, Peoples R China

来源：

JOURNAL OF PERINATAL MEDICINE | 2012年 / 40卷 / 02期

关键词：

CTGF (connective tissue growth factor); Cyr61 (cysteine-rich 61); pre-eclampsia; CCN1; EXPRESSION; HYPOXIA;

D O I：

10.1515/jpm-2011-0035

中图分类号：

R71 [妇产科学];

学科分类号：

100211 [妇产科学];

摘要：

It is thought that a shallow invasion of the maternal decidua by extravillous trophohlasts (EVT) is associated with the development of pre-eclampsia. Here, we focus on the expression of the proangiogenic proteins Cyr61 and CTGF in the human placenta during normal pregnancy compared with that in the late pre-eclamptic placenta. Cyr61 and CTGF are expressed in the extravillous trophoblast and in endothelial cells. We found the expression of Cyr61 was significantly decreased in pre-eclamptic placentas compared with matched controls. In contrast, the CTGF expression level was upregulated in pre-eclamptic placentas. There was a negative correlation between Cyr61 and CTGF. These results suggest that decreased Cyr61 and overexpressed CTGF may play a part in the development of pre-eclampsia.

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收藏

页码：199 / 200

页数：2

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