Neurobiology - A homeostatic switch

被引：37

作者：

Miles, R ^{[1
]}

机构：

[1] Inst Pasteur, INSERM, Lab Neurobiol Cellulaire, U261, Paris 15, France

来源：

NATURE | 1999年 / 397卷 / 6716期

关键词：

D O I：

10.1038/16604

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

During development, some neurons can change their sensitivity to neurotransmitters such as GABA. At birth, these neurons contain high concentrations of Cl− ions, which means that GABA excites them. But just a week after birth, they contain much less intracellular Cl−, and GABA is inhibitory. The protein responsible for this switch has now been identified, and is shown to be a K+/Cl−co-transporter called KCC2.

引用

页码：215 / 216

页数：2

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