The neurobiology of opiate reinforcement

被引：95

作者：

Shippenberg, TS

Elmer, GI

机构：

[1] NIDA, Integrat Neurosci Unit, Behav Neurosci Lab, Intramural Res Program,NIH, Baltimore, MD 21224 USA

[2] Univ Maryland, Sch Med, Maryland Psychiat Res Ctr, Dept Psychiat, Baltimore, MD 21228 USA

来源：

CRITICAL REVIEWS IN NEUROBIOLOGY | 1998年 / 12卷 / 04期

关键词：

opiate reinforcement; opioid peptides; self-administration; conditioned place preference; microdialysis; voltametry;

D O I：

10.1615/CritRevNeurobiol.v12.i4.10

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This article provides a basic introduction into two commonly used behavioral paradigms used for the assessment of the reinforcing and rewarding effects of drugs in experimental animals. Behavioral as well as neurochemical data regarding the neural basis of opiate reward are then critically reviewed in order to evaluate the neuroanatomical and neurochemical substrates mediating the primary and conditioned reinforcing effects of opiates as well as current hypotheses of drug-induced reward and aversion.

引用

页码：267 / 303

页数：37

共 237 条

[1] SCH 23390 BLOCKS DRUG-CONDITIONED PLACE-PREFERENCE AND PLACE-AVERSION - ANHEDONIA (LACK OF REWARD) OR APATHY (LACK OF MOTIVATION) AFTER DOPAMINE-RECEPTOR BLOCKADE [J].