The receptor NLRP3 is a transcriptional regulator of TH2 differentiation

被引：345

作者：

Bruchard, Melanie ^{[1
,2
]}

Rebe, Cedric ^{[1
,2
,3
]}

Derangere, Valentin ^{[1
,2
,3
]}

Togbe, Dieudonnee ^{[4
]}

Ryffel, Bernhard ^{[5
]}

Boidot, Romain ^{[1
,2
,3
]}

Humblin, Etienne ^{[1
,2
]}

Hamman, Arlette ^{[1
,2
]}

Chalmin, Fanny ^{[1
,2
]}

Berger, Helene ^{[1
,2
]}

Chevriaux, Angelique ^{[1
,2
,3
]}

Limagne, Emeric ^{[1
,2
]}

Apetoh, Lionel ^{[1
,2
,3
]}

Vegran, Frederique ^{[1
,2
,3
]}

Ghiringhelli, Francois ^{[1
,2
,3
]}

机构：

[1] INSERM, U866, Dijon, France

[2] Univ Bourgogne, Fac Med, Dijon, France

[3] Ctr Georges Francois Leclerc, Dijon, France

[4] Artimmune, Orleans, France

[5] Univ Orleans, CNRS, Lab Expt & Mol Immunol & Neurogenet, UMR 7355, Orleans, France

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 08期

关键词：

GENE-EXPRESSION; FACTOR IRF4; CELL; INFLAMMASOME; INTERLEUKIN-4; ACTIVATION; TH2; IDENTIFICATION; MECHANISMS; INSIGHTS;

D O I：

10.1038/ni.3202

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The receptor NLRP3 is involved in the formation of the NLRP3 inflammasome that activates caspase-1 and mediates the release of interleukin 1 beta (IL-1 beta) and IL-18. Whether NLRP3 can shape immunological function independently of inflammasomes is unclear. We found that NLRP3 expression in CD4(+) T cells specifically supported a T helper type 2 (T(H)2) transcriptional program in a cell-intrinsic manner. NLRP3, but not the inflammasome adaptor ASC or caspase-1, positively regulated a T(H)2 program. In T(H)2 cells, NLRP3 bound the Il4 promoter and transactivated it in conjunction with the transcription factor IRF4. Nlrp3-deficient T(H)2 cells supported melanoma tumor growth in an IL-4-dependent manner and also promoted asthma-like symptoms. Our results demonstrate the ability of NLRP3 to act as a key transcription factor in T(H)2 differentiation.

引用

收藏

页码：859 / +

页数：15

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