Glutathione and glutathione-related enzymes in reproduction - A review

被引：158

作者：

Knapen, MFCM

Zusterzeel, PLM

Peters, WHM

Steegers, EAP

机构：

[1] Univ Nijmegen St Radboud Hosp, Dept Obstet & Gynaecol, NL-6500 HB Nijmegen, Netherlands

[2] Univ Hosp St Radboud, Dept Gastroenterol, Nijmegen, Netherlands

来源：

EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY | 1999年 / 82卷 / 02期

关键词：

glutathione; reproduction; review; glutathione S-transferase; glutathione peroxidase;

D O I：

10.1016/S0301-2115(98)00242-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Glutathione and glutathione-related enzymes are pivotal for the normal functioning of several important biological processes in humans. Glutathione and glutathione-related enzymes are involved in the metabolism and detoxification of cytotoxic and carcinogenic compounds as well as reactive oxygen species. The role of reactive oxygen species in reproduction was the subject of many investigations, and there is compelling evidence for the involvement of these species in the physiology and pathology of both male and female reproductive systems. The glutathione/glutathione-related enzyme system was extensively studied in gynaecological oncology, but to a lesser extent in other topics related to reproduction. In this paper a review is provided on the glutathione/glutathione-related enzyme system in reproduction. Attention is given to its role as a detoxicating system, and as an tarry marker for disease. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：171 / 184

页数：14

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