Genomic microarrays in the spotlight

被引：128

作者：

Mantripragada, KK ^{[1
]}

Buckley, PG ^{[1
]}

de Ståhl, TD ^{[1
]}

Dumanski, JP ^{[1
]}

机构：

[1] Uppsala Univ, Rudbeck Lab, Dept Genet & Pathol, S-75185 Uppsala, Sweden

来源：

TRENDS IN GENETICS | 2004年 / 20卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tig.2003.12.008

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Microarray-based comparative genomic hybridization (array-CGH) has emerged as a revolutionary platform, enabling the high-resolution detection of DNA copy number aberrations. In this article we outline the use and limitations of genomic clones, cDNA clones and PCR products as targets for genomic microarray construction. Furthermore, the applications and future aspects of these arrays for DNA copy number analysis in research and diagnostics, epigenetic profiling and gene annotation are discussed. These recent developments of genomic microarrays mark only the beginning of a new generation of high-resolution and high-throughput tools for genetic analysis.

引用

页码：87 / 94

页数：8

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