Human interleukin-2 could bind to opioid receptor and induce corresponding signal transduction

被引：29

作者：

Wang, Y

Pei, G

Cai, YC

Zhao, ZQ

Wang, JB

Jiang, CL

Zheng, ZC

Liu, XY

机构：

[1] CHINESE ACAD SCI,SHANGHAI INST BIOCHEM,SHANGHAI 200031,PEOPLES R CHINA

[2] CHINESE ACAD SCI,SHANGHAI INST CELL BIOL,SHANGHAI 200031,PEOPLES R CHINA

[3] CHINESE ACAD SCI,SHANGHAI INST BRAIN SCI,SHANGHAI 200031,PEOPLES R CHINA

[4] UNIV MARYLAND,DEPT PHARMACEUT SCI,BALTIMORE,MD 21201

来源：

NEUROREPORT | 1996年 / 8卷 / 01期

关键词：

analgesic effect; cAMP production; human interleukin-2(IL-2); opioid receptor; pain threshold (PT); signal transduction;

D O I：

10.1097/00001756-199612200-00003

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

INTERLEUKIN-2 (IL-2) was found to have an analgesic effect in the peripheral nervous system. Both electrophysiological and behavioural experiments suggested an anti-noceiceptive effect of IL-2 in animals. Biochemical experiments revealed that IL-2 could displace diprenorphine binding in both NG 108-15 cells and HEK 293 cells transfected with pCDNA3-DOR (delta opioid receptor). Furthermore, IL-2 significantly inhibited cAMP production stimulated by forskolin in both NG 108-15 and transfected HEK 293 cells, indicating that the binding of IL-2 to the delta opioid receptor is functional.

引用

页码：11 / 14

页数：4

共 15 条

[1] STIMULATION OF OLIGODENDROGLIAL PROLIFERATION AND MATURATION BY INTERLEUKIN-2 [J].