Glass transition of a synthetic phospholipid in the lamellar phase

被引：19

作者：

Shalaev, EY

Steponkus, PL

机构：

[1] Pfizer Inc, Groton Labs, Groton, CT 06340 USA

[2] Cornell Univ, Dept Crop & Soil Sci, Ithaca, NY 14853 USA

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2003年 / 107卷 / 34期

关键词：

D O I：

10.1021/jp0303265

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A synthetic phospholipid, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoethanolamine (POPE), was studied by differential scanning calorimetry at different hydration levels. A glass transition was observed in the lamellar gel (L-beta) phase but was not detected in a more ordered lamellar crystalline phase. The glassy state of the L-beta phase of POPE has properties that are typical of other glass-forming materials, i.e., nonexponential relaxation behavior below the glass transition temperature, a broad distribution of relaxation times, and plasticization by water. The significance of the glass transition in biological membranes is discussed.

引用

收藏

页码：8734 / 8737

页数：4

相关论文

共 29 条

[1] FORMATION OF GLASSES FROM LIQUIDS AND BIOPOLYMERS [J].

ANGELL, CA .

SCIENCE, 1995, 267 (5206) :1924-1935

[2]

[Anonymous], 1986, MEMBRANES METABOLISM

[3] PHYSICOCHEMICAL CHARACTERIZATION OF TETRAETHER LIPIDS FROM THERMOPLASMA-ACIDOPHILUM - CALORIMETRIC STUDIES ON MISCIBILITY WITH DIETHER MODEL LIPIDS CARRYING BRANCHED OR UNBRANCHED ALKYL CHAINS [J].

BLOCHER, D ;

SIX, L ;

GUTERMANN, R ;

HENKEL, B ;

RING, K .

BIOCHIMICA ET BIOPHYSICA ACTA, 1985, 818 (03) :333-342

[4] PHYSICOCHEMICAL CHARACTERIZATION OF TETRAETHER LIPIDS FROM THERMOPLASMA-ACIDOPHILUM - DIFFERENTIAL SCANNING CALORIMETRY STUDIES ON GLYCOLIPIDS AND GLYCOPHOSPHOLIPIDS [J].

BLOCHER, D ;

GUTERMANN, R ;

HENKEL, B ;

RING, K .

BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 778 (01) :74-80

[5] Interactions of hydration water and biological membranes studied by neutron scattering [J].

Fitter, J ;

Lechner, RE ;

Dencher, NA .

JOURNAL OF PHYSICAL CHEMISTRY B, 1999, 103 (38) :8036-8050

[6] Phase changes and chemical reactions in solid aqueous solutions: Science and technology [J].

Franks, F .

PURE AND APPLIED CHEMISTRY, 1997, 69 (05) :915-920

[7] IDEAL COPOLYMERS AND THE 2ND-ORDER TRANSITIONS OF SYNTHETIC RUBBERS .1. NON-CRYSTALLINE COPOLYMERS [J].

GORDON, M ;

TAYLOR, JS .

JOURNAL OF APPLIED CHEMISTRY, 1952, 2 (09) :493-500

[8] THE RELATIONSHIP BETWEEN THE GLASS-TRANSITION TEMPERATURE AND THE WATER-CONTENT OF AMORPHOUS PHARMACEUTICAL SOLIDS [J].

HANCOCK, BC ;

ZOGRAFI, G .

PHARMACEUTICAL RESEARCH, 1994, 11 (04) :471-477

[9]

HATAKEYAMA T, 1998, HDB THERMAL ANAL, P69

[10] ENTHALPY RELAXATION AND RECOVERY IN AMORPHOUS MATERIALS [J].

HODGE, IM .

JOURNAL OF NON-CRYSTALLINE SOLIDS, 1994, 169 (03) :211-266