Cytotoxic screening of medicinal and edible plants in Okinawa, Japan, and identification of the main toxic constituent of Rhodea japonica (Omoto)

被引：13

作者：

Masuda, T ^{[1
]}

Oyama, Y

Yamamoto, N

Umebayashi, C

Nakao, H

Toi, Y

Takeda, Y

Nakamoto, K

Kuninaga, H

Nishizato, Y

Nonaka, A

机构：

[1] Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan

[2] Nakazen Inc, Okinawa 9011513, Japan

[3] Univ Ryukyus, Trop Biosphere Res Ctr, Okinawa 9071441, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 06期

关键词：

cytotoxic activity; edible and medicinal plant; Okinawa; Rhodea japonica; rhodexin A;

D O I：

10.1271/bbb.67.1401

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytotoxic activity of ethanol extracts from 53 parts of 36 species of medicinal and edible plants cultivated in Okinawa was measured by using K562 human leukemia cells by a flow cytometric method. Two extracts from Rhodea japonica and Hypericum chinense were cytotoxic at a concentration of 10 mug/ml. The main cytotoxic constituent of Rhodea japonica was isolated and identified to be rhodexin A, which has been isolated as a cardetonic agent of the plant. The IC50 value for rhodexin A against the growth of K562 cells was 19 nm, this activity being much stronger than that of ouabain (IC50, 60 nm).

引用

页码：1401 / 1404

页数：4

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