Treatment on demand -: in vivo dose finding studies

被引：8

作者：

Escobar, MA

机构：

[1] Gulf State Hemophilia & Thrombophilia Ctr, Houston, TX 77030 USA

[2] Univ Texas, Div Hematol, Houston, TX USA

来源：

HAEMOPHILIA | 2003年 / 9卷 / 04期

关键词：

dosage; dose finding studies; factor VIII; factor IX; haemophilia; pharmacokinetics;

D O I：

10.1046/j.1365-2516.2003.00761.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Since the discovery of replacement therapy the goal of treatment for haemophilia patients has always been the prevention of haemorrhagic epsiodes. However, the "ideal" plasma level needed to prevent hemathrosis or treat haemorrhages is still unknown. It seems that the doses of treatment have been arrived at by trial and error based in the pharmacokinetics of the factors and the characteristics of the replacement product. This review provides some guidelines for the treatment of haemophilia, however the doses are not based in randomized trials.

引用

页码：360 / 367

页数：8

共 67 条

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