Trained immunity: A program of innate immune memory in health and disease

被引：1996

作者：

Netea, Mihai G. ^{[1
,2
]}

Joosten, Leo A. B. ^{[1
,2
]}

Latz, Eicke ^{[3
,4
,5
]}

Mills, Kingston H. G. ^{[6
]}

Natoli, Gioacchino ^{[7
]}

Stunnenberg, Hendrik G. ^{[8
,9
]}

O'Neill, Luke A. J. ^{[6
]}

Xavier, Ramnik J. ^{[10
,11
,12
]}

机构：

[1] Radboud Univ Nijmegen, Dept Internal Med, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Radboud Ctr Infect Dis, Med Ctr, NL-6525 ED Nijmegen, Netherlands

[3] Univ Bonn, Inst Innate Immun, Bonn, Germany

[4] Univ Massachusetts, Sch Med, Dept Med, Div Infect Dis & Immunol, Worcester, MA 01655 USA

[5] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[6] Univ Dublin Trinity Coll, Sch Biochem & Immunol, Dublin 2, Ireland

[7] European Inst Oncol, Dept Expt Oncol, Milan, Italy

[8] Radboud Univ Nijmegen, Dept Mol Biol, Fac Sci, Radboud Inst Mol Life Sci, NL-6525 ED Nijmegen, Netherlands

[9] Radboud Univ Nijmegen, Dept Mol Biol, Fac Med, Radboud Inst Mol Life Sci, NL-6525 ED Nijmegen, Netherlands

[10] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[11] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Ctr Computat & Integrat Biol, Boston, MA 02114 USA

[12] Harvard Univ, Massachusetts Gen Hosp, Sch Med, Gastrointestinal Unit, Boston, MA 02114 USA

来源：

SCIENCE | 2016年 / 352卷 / 6284期

基金：

爱尔兰科学基金会; 欧洲研究理事会;

关键词：

NATURAL-KILLER-CELLS; NK CELLS; CANDIDA-ALBICANS; BONE-MARROW; NONSPECIFIC PROTECTION; MACROPHAGE ACTIVATION; CYTOKINE PRODUCTION; CALMETTE-GUERIN; BCG VACCINATION; LOW-VIRULENCE;

D O I：

10.1126/science.aaf1098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

The general view that only adaptive immunity can build immunological memory has recently been challenged. In organisms lacking adaptive immunity, as well as in mammals, the innate immune system can mount resistance to reinfection, a phenomenon termed "trained immunity" or "innate immune memory." Trained immunity is orchestrated by epigenetic reprogramming, broadly defined as sustained changes in gene expression and cell physiology that do not involve permanent genetic changes such as mutations and recombination, which are essential for adaptive immunity. The discovery of trained immunity may open the door for novel vaccine approaches, new therapeutic strategies for the treatment of immune deficiency states, and modulation of exaggerated inflammation in autoinflammatory diseases.

引用

页数：9

共 111 条

[1]

Bone-Marrow-Resident NK Cells Prime Monocytes for Regulatory Function during Infection [J].