Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF

被引：57

作者：

Esumi, N

Budarf, M

Ciccarelli, L

Sellinger, B

Kozak, CA

Wistow, G

机构：

[1] NEI, Sect Mol Struct & Funct, NIH, Bethesda, MD 20892 USA

[2] Univ Penn, Sch Med, Dept Pediat, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

[4] NIAID, Mol Microbiol Lab, NIH, Bethesda, MD 20892 USA

来源：

MAMMALIAN GENOME | 1998年 / 9卷 / 09期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1007/s003359900858

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Macrophage migration inhibitory factor (MIF) and D-dopachrome tautomerase (DDT) are small proteins, which are related both by sequence and by in vitro enzyme activity. Here we show that the gene for DDT in human and mouse is identical in exon structure to MIF. Both genes have two introns that are located at equivalent positions, relative to a twofold repeat in protein structure. Although in similar positions, the introns are in different phases relative to the open reading frame. Other members of this superfamily exist in nematodes and a plant, and a related gene in C, elegans shares an intron position with MIF and DDT. Ln addition to similarities in structure, the genes for DDT and MIF are closely linked on human Chromosome (Chr) 22 and mouse Chr 10.

引用

页码：753 / 757

页数：5

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