Cell Biology of Astrocyte-Synapse Interactions

被引:786
作者
Allen, Nicola J. [1 ]
Eroglu, Cagla [2 ,3 ,4 ]
机构
[1] Salk Inst Biol Studies, Mol Neurobiol Lab, 10010 North Torrey Pines Rd, La Jolla, CA 92037 USA
[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA
[3] Duke Univ, Med Ctr, Dept Neurobiol, Durham, NC 27710 USA
[4] Duke Univ, Med Ctr, Duke Inst Brain Sci, Durham, NC 27710 USA
关键词
CNS SYNAPTOGENESIS; PERISYNAPTIC ASTROGLIA; NEUROMUSCULAR-JUNCTION; HIPPOCAMPAL-NEURONS; SECRETED PROTEINS; STEM-CELLS; GLIA; PLASTICITY; MATURATION; BRAIN;
D O I
10.1016/j.neuron.2017.09.056
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Astrocytes, the most abundant glial cells in the mammalian brain, are critical regulators of brain development and physiology through dynamic and often bidirectional interactions with neuronal synapses. Despite the clear importance of astrocytes for the establishment and maintenance of proper synaptic connectivity, our understanding of their role in brain function is still in its infancy. We propose that this is at least in part due to large gaps in our knowledge of the cell biology of astrocytes and the mechanisms they use to interact with synapses. In this review, we summarize some of the seminal findings that yield important insight into the cellular and molecular basis of astrocyte-neuron communication, focusing on the role of astrocytes in the development and remodeling of synapses. Furthermore, we pose some pressing questions that need to be addressed to advance our mechanistic understanding of the role of astrocytes in regulating synaptic development.
引用
收藏
页码:697 / 708
页数:12
相关论文
共 135 条
[1]
What is the role of astrocyte calcium in neurophysiology? [J].
Agulhon, Cendra ;
Petravicz, Jeremy ;
McMullen, Allison B. ;
Sweger, Elizabeth J. ;
Minton, Suzanne K. ;
Taves, Sarah R. ;
Casper, Kristen B. ;
Fiacco, Todd A. ;
McCarthy, Ken D. .
NEURON, 2008, 59 (06) :932-946
[2]
SPARC prevents maturation of cholinergic presynaptic terminals [J].
Albrecht, David ;
Jose Lopez-Murcia, Francisco ;
Perez-Gonzalez, Anna P. ;
Lichtner, Gregor ;
Solsona, Carles ;
Llobet, Artur .
MOLECULAR AND CELLULAR NEUROSCIENCE, 2012, 49 (03) :364-374
[3]
Astrocyte Regulation of Synaptic Behavior [J].
Allen, Nicola J. .
ANNUAL REVIEW OF CELL AND DEVELOPMENTAL BIOLOGY, VOL 30, 2014, 30 :439-463
[4]
Astrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors [J].
Allen, Nicola J. ;
Bennett, Mariko L. ;
Foo, Lynette C. ;
Wang, Gordon X. ;
Chakraborty, Chandrani ;
Smith, Stephen J. ;
Barres, Ben A. .
NATURE, 2012, 486 (7403) :410-+
[5]
Tripartite synapses: glia, the unacknowledged partner [J].
Araque, A ;
Parpura, V ;
Sanzgiri, RP ;
Haydon, PG .
TRENDS IN NEUROSCIENCES, 1999, 22 (05) :208-215
[6]
Gliotransmitters Travel in Time and Space [J].
Araque, Alfonso ;
Carmignoto, Giorgio ;
Haydon, Philip G. ;
Oliet, Stephane H. R. ;
Robitaille, Richard ;
Volterra, Andrea .
NEURON, 2014, 81 (04) :728-739
[7]
Molecular mechanisms of astrocyte-induced synaptogenesis [J].
Baldwin, Katherine T. ;
Eroglu, Cagla .
CURRENT OPINION IN NEUROBIOLOGY, 2017, 45 :113-120
[8]
Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology [J].
Ballas, Nurit ;
Lioy, Daniel T. ;
Grunseich, Christopher ;
Mandel, Gail .
NATURE NEUROSCIENCE, 2009, 12 (03) :311-317
[9]
TROPHIC INTERACTIONS BETWEEN ASTROGLIAL CELLS AND HIPPOCAMPAL-NEURONS IN CULTURE [J].
BANKER, GA .
SCIENCE, 1980, 209 (4458) :809-810
[10]
Developmental control of synaptic receptivity [J].
Barker, Alison J. ;
Koch, Selina M. ;
Reed, Jamian ;
Barres, Ben A. ;
Ullian, Erik M. .
JOURNAL OF NEUROSCIENCE, 2008, 28 (33) :8150-8160