Synthesis, biological evaluation and molecular modeling studies of arylidene-thiazolidinediones with potential hypoglycemic and hypolipidemic activities

被引：55

作者：

da Costa Leite, Lucia Fernanda C.

Veras Mourao, Rosa Helena

Alves de Lima, Maria do Carmo

Galdino, Suely Lins

Hernandes, Marcelo Zaldini

Rocha Neves, Francisco de Assis

Vidal, Stephanie

Barbe, Jacques

Pitta, Ivan da Rocha ^{[1
]}

机构：

[1] Univ Fed Pernambuco, Dept Antibioticos, BR-50670901 Recife, PE, Brazil

[2] Univ Catolica Pernambuco, Dept Quim, BR-50050900 Recife, PE, Brazil

[3] Univ Brasilia, BR-70910900 Brasilia, DF, Brazil

[4] Univ Mediterranee, Fac Pharm, GERCTOP, CNRS,UMR 6178, F-13385 Marseille 5, France

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 10期

关键词：

arylidene-thiazolidinediones; hypoglycemic; hypolipidemic; molecular modeling; docking;

D O I：

10.1016/j.ejmech.2007.02.015

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

New arylidene-thiazolidinediones (ATZDs) were synthesized and evaluated in the alloxan-induced hyperglycemia mice model. The molecular target taken into consideration is the nuclear PPAR-gamma whose crystallographic structure is available on the PDB database as 2PRG. Thus the hypoglycemic and hypolipidemic activities of compounds were compared with the result of their docking after removal of the co-crystallized ligand present in the 2PRG structure. Molecular modeling studies were carried out using the Autodock 3.0.5 and ADT 1.1 programs. (c) 2007 Elsevier Masson SAS. All rights reserved.

引用

页码：1263 / 1271

页数：9

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