Nonalcoholic steatohepatitis and increased risk of chronic kidney disease

被引：135

作者：

Yasui, Kohichiroh ^{[1
]}

Sumida, Yoshio ^{[2
]}

Mori, Yasukiyo ^{[3
]}

Mitsuyoshi, Hironori ^{[1
]}

Minami, Masahito ^{[1
]}

Itoh, Yoshito ^{[1
]}

Kanemasa, Kazuyuki ^{[2
]}

Matsubara, Hiroaki ^{[3
,4
]}

Okanoue, Takeshi ^{[5
]}

Yoshikawa, Toshikazu ^{[1
]}

机构：

[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Mol Gastroenterol & Hepatol, Kamigyo Ku, Kyoto 6028566, Japan

[2] Nara City Hosp, Ctr Digest & Liver Dis, Nara 6308305, Japan

[3] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Nephrol, Kamigyo Ku, Kyoto 6028566, Japan

[4] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Dept Cardiovasc Med, Kamigyo Ku, Kyoto 6028566, Japan

[5] Saiseikai Suita Hosp, Ctr Gastroenterol & Hepatol, Suita, Osaka 5640013, Japan

来源：

METABOLISM-CLINICAL AND EXPERIMENTAL | 2011年 / 60卷 / 05期

关键词：

FATTY LIVER-DISEASE; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; METABOLIC SYNDROME; FOLLOW-UP; CLASSIFICATION;

D O I：

10.1016/j.metabol.2010.07.022

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Nonalcoholic fatty liver disease (NAFLD) and chronic kidney disease (CKD) share common features. Both are associated with visceral obesity, type 2 diabetes mellitus, metabolic syndrome, and insulin resistance. However, the relationship between NAFLD and CKD is poorly understood. We examined the prevalence of and risk factors for CKD in patients with NAFLD. We analyzed 174 Japanese patients With liver biopsy proven NAFLD using a cross-sectional design. Chronic kidney disease was defined as estimated glomerular filtration. rate less than 60 mL/min per 1.73 m(2) and/or overt proteinuria. Of 174 NAFLD patients, 92 (53%) exhibited histologic characteristics of nonalcoholic steatohepatitis (NASH), the progressive form of NAFLD; and 82 (47%) had non-NASH NAFLD. Chronic kidney disease was present in 24 (14%) of 174 NAFLD patients. the prevalence:of CKD was significantly higher in NASH patients (19 of 92; 21%) than non-NASH patients (5 of 82; 6%). The presence of CKD was associated with a higher body mass index and the presence of hypertension and NASH. Our results demonstrated a high prevalence of CKD among patients with NASH. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：735 / 739

页数：5

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