Towards an HIV-1 cure: measuring the latent reservoir

被引：179

作者：

Bruner, Katherine M. ^{[1
]}

Hosmane, Nina N. ^{[1
]}

Siliciano, Robert F. ^{[1
,2
]}

机构：

[1] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21205 USA

来源：

TRENDS IN MICROBIOLOGY | 2015年 / 23卷 / 04期

基金：

美国国家卫生研究院;

关键词：

HIV-1; cure; latency; assays; HUMAN-IMMUNODEFICIENCY-VIRUS; CD4(+) T-CELLS; ANTIRETROVIRAL THERAPY; RALTEGRAVIR INTENSIFICATION; DRUG-RESISTANCE; RESIDUAL HIV-1; PLASMA VIREMIA; QUANTITATIVE ASSAY; INFECTED PATIENTS; VIRAL LOAD;

D O I：

10.1016/j.tim.2015.01.013

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The latent reservoir (LR) of HIV-1 in resting memory CD4(+) T cells serves as a major barrier to curing HIV-1 infection. While many PCR- and culture-based assays have been used to measure the size of the LR, correlation between results of different assays is poor and recent studies indicate that no available assay provides an accurate measurement of reservoir size. The discrepancies between assays are a hurdle to clinical trials that aim to measure the efficacy of HIV-1 eradication strategies. Here we describe the advantages and disadvantages of various approaches to measuring the LR.

引用

页码：192 / 203

页数：12

共 109 条

[1]

Clonal Sequences Recovered from Plasma from Patients with Residual HIV-1 Viremia and on Intensified Antiretroviral Therapy Are Identical to Replicating Viral RNAs Recovered from Circulating Resting CD4+ T Cells [J].

Anderson, Jeffrey A. ;

Archin, Nancie M. ;

Ince, William ;

Parker, Daniel ;

Wiegand, Ann ;

Coffin, John M. ;

Kuruc, Joann ;

Eron, Joseph ;

Swanstrom, Ronald ;

Margolis, David M. .

JOURNAL OF VIROLOGY, 2011, 85 (10) :5220-5223

[2]

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy [J].

Archin, N. M. ;

Liberty, A. L. ;

Kashuba, A. D. ;

Choudhary, S. K. ;

Kuruc, J. D. ;

Crooks, A. M. ;

Parker, D. C. ;

Anderson, E. M. ;

Kearney, M. F. ;

Strain, M. C. ;

Richman, D. D. ;

Hudgens, M. G. ;

Bosch, R. J. ;

Coffin, J. M. ;

Eron, J. J. ;

Hazuda, D. J. ;

Margolis, D. M. .

NATURE, 2012, 487 (7408) :482-U1650

[3]

Emerging strategies to deplete the HIV reservoir [J].

Archin, Nancie M. ;

Margolis, David M. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2014, 27 (01) :29-35

[4]

Antiretroviral Intensification and Valproic Acid Lack Sustained Effect on Residual HIV-1 Viremia or Resting CD4+Cell Infection [J].

Archin, Nancie M. ;

Cheema, Manzoor ;

Parker, Daniel ;

Wiegand, Ann ;

Bosch, Ronald J. ;

Coffin, John M. ;

Eron, Joseph ;

Cohen, Myron ;

Margolis, David M. .

PLOS ONE, 2010, 5 (02)

[5]

Expression of Latent HIV Induced by the Potent HDAC Inhibitor Suberoylanilide Hydroxamic Acid [J].

Archin, Nancie M. ;

Espeseth, Amy ;

Parker, Daniel ;

Cheema, Manzoor ;

Hazuda, Daria ;

Margolis, David M. .

AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (02) :207-212

[6]

HIV-1 Expression Within Resting CD4+ T Cells After Multiple Doses of Vorinostat [J].

Archin, Nancy M. ;

Bateson, Rosalie ;

Tripathy, Manoj K. ;

Crooks, Amanda M. ;

Yang, Kuo-Hsiung ;

Dahl, Noelle P. ;

Kearney, Mary F. ;

Anderson, Elizabeth M. ;

Coffin, John M. ;

Strain, Matthew C. ;

Richman, Douglas D. ;

Robertson, Kevin R. ;

Kashuba, Angela D. ;

Bosch, Ronald J. ;

Hazuda, Daria J. ;

Kuruc, Joann D. ;

Eron, Joseph J. ;

Margolis, David M. .

JOURNAL OF INFECTIOUS DISEASES, 2014, 210 (05) :728-735

[7]

Risk of selecting de novo drug-resistance mutations during structured treatment interruptions in patients with chronic HIV infection [J].

Arnedo-Valero, M ;

García, F ;

Gil, C ;

Guila, T ;

Fumero, E ;

Castro, P ;

Blanco, JL ;

Miró, JM ;

Pumarola, T ;

Gatell, JM .

CLINICAL INFECTIOUS DISEASES, 2005, 41 (06) :883-890

[8]

Residual human immunodeficiency virus type 1 viremia in some patients on Antiretroviral therapy is dominated by a small number of invariant clones rarely found in circulating CD4+ T cells [J].

Bailey, JR ;

Sedaghat, AR ;

Kieffer, T ;

Brennan, T ;

Lee, PK ;

Wind-Rotolo, M ;

Haggerty, CM ;

Kamireddi, AR ;

Liu, Y ;

Lee, J ;

Persaud, D ;

Gallant, JE ;

Cofrancesco, J ;

Quinn, TC ;

Wilke, CO ;

Ray, SC ;

Siliciano, JD ;

Nettles, RE ;

Siliciano, RF .

JOURNAL OF VIROLOGY, 2006, 80 (13) :6441-6457

[9]

Short-Course Raltegravir Intensification Does Not Increase 2 Long Terminal Repeat Episomal HIV-1 DNA in Patients on Effective Antiretroviral Therapy [J].

Besson, Guillaume J. ;

McMahon, Deborah ;

Maldarelli, Frank ;

Mellors, John W. .

CLINICAL INFECTIOUS DISEASES, 2012, 54 (03) :451-453

[10]

Biphasic decay of latently infected CD4+ T cells in acute human immunodeficiency virus type 1 infection [J].

Blankson, JN ;

Finzi, D ;

Pierson, TC ;

Sabundayo, BP ;

Chadwick, K ;

Margolick, JB ;

Quinn, TC ;

Siliciano, RF .

JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (06) :1636-1642

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