4-Oxoazetidine-2-carbaldehydes as useful building blocks in stereocontrolled synthesis

被引：181

作者：

Alcaide, B ^{[1
]}

Almendros, P ^{[1
]}

机构：

[1] Univ Complutense, Fac Ciencias Quim, Dept Quim Organ 1, E-28040 Madrid, Spain

来源：

CHEMICAL SOCIETY REVIEWS | 2001年 / 30卷 / 04期

关键词：

D O I：

10.1039/b007908l

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4-Oxoazetidine-2-carbaldehydes or 4-formyl-beta -lactams can be considered both as protected alpha -amino aldehydes and masked beta -amino acids. These bifunctional compounds exhibit a valuable dual reactivity, which has been utilized in a broad range of synthetic applications. The present review is a survey of the recent salient synthetic achievements exploiting 4-oxoazetidine-2-carbaldehydes, with particular emphasis on diastereoselective processes. The usefulness of these substrates for the preparation of substances of biological interest, including alpha -amino acids, b-amino acids, amino sugars, polycyclic-beta -lactams, alkaloids, and complex natural products is presented.

引用

页码：226 / 240

页数：15

共 46 条

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