Analysis of Chinese herbal medicines with holistic approaches and integrated evaluation models

被引：150

作者：

Li, Ping ^{[1
]}

Qi, Lian-Wen ^{[1
]}

Liu, E-Hu ^{[1
]}

Zhou, Jian-Liang ^{[1
]}

Wen, Xiao-Dong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Key Lab Modern Chinese Med, Minist Educ, Nanjing 210009, Peoples R China

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2008年 / 27卷 / 01期

基金：

中国国家自然科学基金;

关键词：

absorption; distribution; metabolism and excretion; ADME; capillary electrophoresis combined with mass spectrometry; CE-MS; Chinese herbal medicine; chromatographic fingerprinting; gas chromatography combined with mass spectrometry; GC-MS; holistic approaches and integrated evaluation models; HAIEMs;

D O I：

10.1016/j.trac.2007.11.005

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This overview covers current strategies for the analysis of Chinese herbal medicines (CHMs) with holistic approaches and integrated evaluation models (HAIEMs). We start by discussing the analytical techniques used in HAIEMs for research on CHMs, including gas chromatography, liquid chromatography, and capillary electrophoresis. We also describe application of HAIEMs for quality control, elucidation of the properties of absorption, distribution, metabolism and excretion, and metabonomics evaluation of CHMs. HAIEMs are well matched to global and interactive aspects of the non-linear dynamic complex systems of CHMs, and offer the possibility of evaluating whole systems of CHMs. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：66 / 77

页数：12

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