Genome Editing Technologies: Defining a Path to Clinic

被引：79

作者：

Corrigan-Curay, Jacqueline ^{[1
]}

O'Reilly, Marina ^{[1
]}

Kohn, Donald B. ^{[2
]}

Cannon, Paula M. ^{[3
]}

Bao, Gang ^{[4
]}

Bushman, Frederic D. ^{[5
]}

Carroll, Dana ^{[6
]}

Cathomen, Toni ^{[7
]}

Joung, J. Keith ^{[8
,9
]}

Roth, David ^{[5
]}

Sadelain, Michel ^{[10
]}

Scharenberg, Andrew M. ^{[11
,12
]}

von Kalle, Christof ^{[13
,14
]}

Zhang, Feng ^{[15
,16
]}

Jambou, Robert ^{[1
]}

Rosenthal, Eugene ^{[1
]}

Hassani, Morad ^{[1
]}

Singh, Aparna ^{[1
]}

Porteus, Matthew H. ^{[17
]}

机构：

[1] NIH, Bethesda, MD 20892 USA

[2] Univ Calif Los Angeles, Los Angeles, CA USA

[3] Univ So Calif, Keck Sch Med, Los Angeles, CA 90033 USA

[4] Georgia Inst Technol, Atlanta, GA 30332 USA

[5] Univ Penn, Sch Med, Philadelphia, PA 19104 USA

[6] Univ Utah, Sch Med, Salt Lake City, UT USA

[7] Univ Med Ctr, Freiberg, Germany

[8] Massachusetts Gen Hosp, Charlestown, MA USA

[9] Harvard Univ, Sch Med, Boston, MA USA

[10] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[11] Seattle Childrens Res Inst, Seattle, WA USA

[12] Univ Washington, Sch Med, Seattle, WA USA

[13] Natl Ctr Tumor Dis, Heidelberg, Germany

[14] German Canc Res Ctr, Heidelberg, Germany

[15] MIT, Cambridge, MA 02139 USA

[16] Harvard Univ, Cambridge, MA 02138 USA

[17] Stanford Univ, Stanford, CA 94305 USA

来源：

MOLECULAR THERAPY | 2015年 / 23卷 / 05期

关键词：

ZINC-FINGER NUCLEASES; ACUTE LYMPHOBLASTIC-LEUKEMIA; RAG-MEDIATED RECOMBINATION; HUMAN-CELLS; MAMMALIAN-CELLS; GENE-THERAPY; IN-VITRO; T-CELLS; DNA; SPECIFICITY;

D O I：

10.1038/mt.2015.54

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：796 / 806

页数：11

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