The linear process of somatic evolution

被引:138
作者
Nowak, MA [1 ]
Michor, F
Iwasa, Y
机构
[1] Harvard Univ, Program Evolutionary Dynam, Cambridge, MA 02138 USA
[2] Kyushu Univ, Dept Biol, Fukuoka 8128581, Japan
关键词
D O I
10.1073/pnas.2535419100
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cancer is the consequence of an unwanted evolutionary process. Cells receive mutations that alter their phenotype. Especially dangerous are those mutations that increase the net reproductive rate of cells, thereby leading to neoplasia and later to cancer. The standard models of evolutionary dynamics consider well mixed populations of individuals in symmetric positions. Here we introduce a spatially explicit, asymmetric stochastic process that captures the essential architecture of evolutionary dynamics operating within tissues of multicellular organisms. The "linear process" has the property of canceling out selective differences among cells yet retaining the protective function of apoptosis. This design can slow down the rate of somatic evolution dramatically and therefore delay the onset of cancer.
引用
收藏
页码:14966 / 14969
页数:4
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