Pharmaco-metabolomics: An emerging "omics" tool for the personalization of anticancer treatments and identification of new valuable therapeutic targets

被引：63

作者：

Corona, Giuseppe ^{[1
]}

Rizzolio, Flavio ^{[1
,2
,3
]}

Giordano, Antonio ^{[2
,3
]}

Toffoli, Giuseppe ^{[1
]}

机构：

[1] Natl Canc Inst, IRCCS, Expt & Clin Pharmacol Div, Aviano, Pordenone, Italy

[2] Temple Univ, Coll Sci & Technol, Sbarro Inst Canc Res & Mol Med, Philadelphia, PA 19122 USA

[3] Temple Univ, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2012年 / 227卷 / 07期

关键词：

CHEMOSENSITIVITY PREDICTION; CANCER PATIENTS; METABOLISM; SPECTROSCOPY; METABONOMICS; INHIBITOR; APOPTOSIS; DISEASE;

D O I：

10.1002/jcp.24003

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In the post-genomics era, metabolomics represents a new omics approach that in the last decade has received increased attention in the field of oncology. Metabolomics is based on the holistic study of the metabolic profile that characterizes a specific phenotype in a biological system. The metabolic profile provides a readout of the metabolic state of an individual that cannot be obtained directly from DNA genotyping, gene expression, or proteomic profiling analyses. The translational value of metabonomics in the oncology field has been demonstrated by the identification of diagnostic and prognostic biomarkers. The so-called pharmaco-metabolomic approach that is currently emerging aims to identify the individual metabolomic characteristics able to predict drug effectiveness and/or toxicity. This review presents the potential role of pharmaco-metabolomics in the future of anticancer pharmacology to achieve customized anticancer treatments and new, targeted therapeutic approaches. J. Cell. Physiol. 227: 28272831, 2012. (C) 2011 Wiley Periodicals, Inc.

引用

页码：2827 / 2831

页数：5

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