Cutis laxa: A review

被引：130

作者：

Berk, David R. ^{[1
,2
]}

Bentley, Danette D. ^{[4
]}

Bayliss, Susan J. ^{[1
,2
]}

Lind, Anne ^{[3
]}

Urban, Zsolt ^{[5
]}

机构：

[1] Washington Univ, Sch Med, Div Dermatol, Dept Internal Med, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Div Dermatol, Dept Pediat, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA

[4] Univ Alabama Birmingham, Sch Med, Dept Dermatol, Birmingham, AL USA

[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Human Genet, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY | 2012年 / 66卷 / 05期

基金：

美国国家卫生研究院;

关键词：

cutis laxa; elastic tissue; elastin; fibulin-4; fibulin-5; genodermatosis; OCCIPITAL HORN SYNDROME; BETA-BINDING-PROTEINS; ARTERIAL-TORTUOSITY-SYNDROME; AUTOSOMAL-RECESSIVE FORM; ELASTIC FIBER FORMATION; SPLICE-SITE MUTATIONS; MENKES-DISEASE; PSEUDOXANTHOMA ELASTICUM; ATP7A GENE; TGF-BETA;

D O I：

10.1016/j.jaad.2011.01.004

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100227 [皮肤病学];

摘要：

Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated. (J Am Acad Dermatol 2012;66:842.e1-17.)

引用

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