Tetraploid development in the mouse

被引:64
作者
Eakin, GS
Behringer, RR
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol Genet, Houston, TX 77030 USA
[2] Univ Texas, MD Anderson Canc Ctr, Baylor Coll Med, Program Dev Biol, Houston, TX 77030 USA
关键词
tetraploid; genome duplication; nuclear transplantation; endoduplication; cell fusion; mouse chimeras;
D O I
10.1002/dvdy.10363
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
Spontaneous duplication of the mammalian genome occurs in approximately 1% of fertilizations. Although one or more whole genome duplications are believed to have influenced vertebrate evolution, polyploidy of contemporary mammals is generally incompatible with normal development and function of all but a few tissues. The production of tetraploid (4n) embryos has become a common experimental manipulation in the mouse. Although development of tetraploid mice has generally not been observed beyond midgestation, tetraploid:diploid (4n:2n) chimeras are widely used as a method for rescuing extraembryonic defects. The tolerance of tissues to polyploidy appears to be dependent on genetic background. Indeed, the recent discovery of a naturally tetraploid rodent species suggests that, in rare genetic backgrounds, mammalian genome duplications may be compatible with the development of viable and fertile adults. Thus, the range of developmental potentials of tetraploid embryos remains in large part unexplored. Here, we review the biological consequences and experimental utility of tetraploid mammals, in particular the mouse. (C) 2003 Wiley-Liss, Inc.
引用
收藏
页码:751 / 766
页数:16
相关论文
共 147 条
[1]   The developmental potential of the inner cell mass of blastocysts that were derived from mouse ES cells using nuclear transfer technology [J].
Amano, T ;
Kato, Y ;
Tsunoda, Y .
CELL AND TISSUE RESEARCH, 2002, 307 (03) :367-370
[2]   Comparison of heat-treated and tetraploid blastocysts for the production of completely ES-cell-derived mice [J].
Amano, T ;
Kato, Y ;
Tsunoda, Y .
ZYGOTE, 2001, 9 (02) :153-157
[3]   Fgfr2 is required for limb outgrowth and lung-branching morphogenesis [J].
Arman, E ;
Haffner-Krausz, R ;
Gorivodsky, M ;
Lonai, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (21) :11895-11899
[4]   PPARγ is required for placental, cardiac, and adipose tissue development [J].
Barak, Y ;
Nelson, MC ;
Ong, ES ;
Jones, YZ ;
Ruiz-Lozano, P ;
Chien, KR ;
Koder, A ;
Evans, RM .
MOLECULAR CELL, 1999, 4 (04) :585-595
[5]  
Baranov V S, 1976, Ontogenez, V7, P229
[7]   HETEROPLOIDY IN MAMMALS .3. INDUCTION OF TETRAPLOIDY IN PRE-IMPLANTATION MOUSE EGGS [J].
BEATTY, RA ;
FISCHBERG, M .
JOURNAL OF GENETICS, 1952, 50 (03) :471-479
[8]  
BEATTY RA, 1951, J EXP BIOL, V28, P541
[9]  
BEDDINGTON RSP, 1989, DEVELOPMENT, V105, P733
[10]  
BERG H, 1987, STUD BIOPHYS, V119, P17