Synthesis and biological evaluation of vinylogous combretastatin A-4 derivatives

被引：39

作者：

Kaffy, J ^{[1
]}

Pontikis, RE ^{[1
]}

Florent, JC ^{[1
]}

Monneret, C ^{[1
]}

机构：

[1] Inst Curie, Sect Rech, CNRS, UMR 176, F-75248 Paris, France

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2005年 / 3卷 / 14期

关键词：

D O I：

10.1039/b505955k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Stereospecific syntheses of the Z-E and E-Z vinylogues of combretastatin A-4, and two B-ring related analogues, were achieved through a Suzuki-Miyaura coupling. As compared to CA4, the derivative with a phenyl moiety has shown increased potency in its ability to inhibit tubulin polymerisation.

引用

页码：2657 / 2660

页数：4

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