No replication of the association between the Nicastrin gene and familial early-onset Alzheimer's disease

被引：9

作者：

Cousin, E

Hannequin, D

Macé, S

Dubois, B

Ricard, S

Génin, E

Brun, C

Chansac, C

Pradier, L

Frebourg, T

Brice, A

Campion, D

Deleuze, JF

机构：

[1] INSERM, Fac Med, IFRMP, F-76000 Rouen, France

[2] Aventis Pharma, Paris Res Ctr, Evry Genet Ctr, F-94400 Vitry Sur Seine, France

[3] Aventis Pharma, Paris Res Ctr, Neudegenerat Dis Grp, F-94400 Vitry Sur Seine, France

[4] Hop La Pitie Salpetriere, Fed Neurol, AP HP, F-75013 Paris, France

[5] Hop La Pitie Salpetriere, INSERM, EPI 007, F-75013 Paris, France

[6] Hop Paul Brousse, INSERM, U535, Secteur Jaune, F-94817 Villejuif, France

[7] Hop La Pitie Salpetriere, INSERM, U289, F-75013 Paris, France

来源：

NEUROSCIENCE LETTERS | 2003年 / 353卷 / 02期

关键词：

Alzheimer's disease; nicastrin; polymorphism;

D O I：

10.1016/S0304-3940(03)01105-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Polymorphisms in the Nicastrin (NCSTN) gene have recently been associated with familial early-onset Alzheimer's disease (AD). The authors genotyped four NCTSN polymorphisms in a large cohort of 489 AD cases (including 158 sporadic early-onset AD cases and 95 familial early-onset AD cases) and 386 controls but failed to replicate the association between NCSTN haplotype B and AD. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：153 / 155

页数：3

共 8 条

[1]

[Anonymous], 1982, CASE CONTROL STUDIES

[2] Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum [J].

Campion, D ;

Dumanchin, C ;

Hannequin, D ;

Dubois, B ;

Belliard, S ;

Puel, M ;

Thomas-Anterion, C ;

Michon, A ;

Martin, C ;

Charbonnier, F ;

Raux, G ;

Camuzat, A ;

Penet, C ;

Mesnage, V ;

Martinez, M ;

Clerget-Darpoux, F ;

Brice, A ;

Frebourg, T .

AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (03) :664-670

[3] The gene encoding nicastrin, a major γ-secretase component, modifies risk for familial early-onset Alzheimer disease in a Dutch population-based sample [J].

Dermaut, B ;

Theuns, J ;

Sleegers, K ;

Hasegawa, H ;

Van den Broeck, M ;

Vennekens, K ;

Corsmit, E ;

St George-Hyslop, P ;

Cruts, M ;

van Duijn, CM ;

Van Broeckhoven, C .

AMERICAN JOURNAL OF HUMAN GENETICS, 2002, 70 (06) :1568-1574

[4] A full genome scan for late onset Alzheimer's disease [J].

Kehoe, P ;

Wavrant-De Vrieze, F ;

Crook, R ;

Wu, WS ;

Holmans, P ;

Fenton, I ;

Spurlock, G ;

Norton, N ;

Williams, H ;

Williams, N ;

Lovestone, S ;

Perez-Tur, J ;

Hutton, M ;

Chartier-Harlin, MC ;

Shears, S ;

Roehl, K ;

Booth, J ;

Van Voorst, W ;

Ramic, D ;

Williams, J ;

Goate, A ;

Hardy, J ;

Owen, MJ .

HUMAN MOLECULAR GENETICS, 1999, 8 (02) :237-245

[5]

MCKHANN G, 1984, NEUROLOGY, V34, P939, DOI 10.1212/WNL.34.7.939

[6] Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing [J].

Yu, G ;

Nishimura, M ;

Arawaka, S ;

Levitan, D ;

Zhang, LL ;

Tandon, A ;

Song, YQ ;

Rogaeva, E ;

Chen, FS ;

Kawaral, T ;

Supala, A ;

Levesque, L ;

Yu, H ;

Yang, DS ;

Holmes, E ;

Millman, P ;

Liang, Y ;

Zhang, DM ;

Xu, DH ;

Sato, C ;

Rogaev, E ;

Smith, M ;

Janus, C ;

Zhang, YN ;

Aebersold, R ;

Farrer, L ;

Sorbi, S ;

Bruni, A ;

Fraser, P ;

St George-Hyslop, P .

NATURE, 2000, 407 (6800) :48-54

[7] Model-free analysis and permutation tests for allelic associations [J].

Zhao, JH ;

Curtis, D ;

Sham, PC .

HUMAN HEREDITY, 2000, 50 (02) :133-139

[8] A genome survey for novel Alzheimer disease risk loci: Results at 10-cM resolution [J].

Zubenko, GS ;

Hughes, HB ;

Stiffler, JS ;

Hurtt, MR ;

Kaplan, BB .

GENOMICS, 1998, 50 (02) :121-128

← 1 →