Potential therapeutic effects of curcumin in gastric cancer

被引：88

作者：

Barati, Nastaran ^{[1
]}

Momtazi-Borojeni, Amir A. ^{[2
,3
]}

Majeed, Muhammed ^{[4
]}

Sahebkar, Amirhossein ^{[5
,6
,7
]}

机构：

[1] Hamadan Univ Med Sci, Deputy Res & Technol, Hamadan, Iran

[2] Mashhad Univ Med Sci, Bu Ali Res Inst, Nanotechnol Res Ctr, Mashhad, Iran

[3] Mashhad Univ Med Sci, Dept Med Biotechnol, Student Res Comm, Fac Med, Mashhad, Iran

[4] Sabinsa Corp, East Windsor, NJ USA

[5] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2019年 / 234卷 / 03期

关键词：

apoptosis; chemosensitization; curcumin; gastric cancer; phytochemical; FACTOR-KAPPA-B; CHRONIC PULMONARY COMPLICATIONS; DRUG-DELIVERY SYSTEM; FATTY LIVER-DISEASE; MOLECULAR TARGETS; IN-VITRO; INHIBITS PROLIFERATION; ANTITUMOR-ACTIVITY; CLINICAL-PRACTICE; SUPPRESSOR-CELLS;

D O I：

10.1002/jcp.27229

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Despite recent advancements in understanding of the biology of gastric cancer, treatment of patients with advanced gastric cancer remains a major problem. Among different type of phytochemicals, curcumin, a welltable -known phytochemical, has been shown to be a promising cancer chemopreventive agent. Pharmacokinetics, safety, and efficacy of curcumin have been evaluated in several clinical trials against numerous diseases, and for the treatment of human cancer. In the present review, we have collected in vitro and in vivo investigations and studied the chemosensitizing and anticancer effects of curcumin against the gastric cancer cells. In summary, curcumin has been found to have efficient chemosensitizing effect and also inhibits viability, proliferation, and migration of gastric cancer cells mainly via cell cycle arrest and induction of apoptosis by both mitochondrial-dependent and -independent pathways.

引用

页码：2317 / 2328

页数：12

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