Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid-phase domains of DMPC lipid bilayers

被引：119

作者：

Mecke, A

Lee, DK

Ramamoorthy, A

Orr, BG ^{[1
]}

Holl, MMB

机构：

[1] Univ Michigan, Dept Phys, Ann Arbor, MI 48109 USA

[2] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Appl Phys Program, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Ctr Biol Nanotechnol, Ann Arbor, MI 48109 USA

[5] Univ Michigan, Div Biophys Res, Ann Arbor, MI 48109 USA

来源：

LANGMUIR | 2005年 / 21卷 / 19期

关键词：

D O I：

10.1021/la051800w

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polycationic polymers are known to disrupt lipid bilayers. In this letter, we report the dependence of this disruption on the lipid structural phase. DMPC bilayers are exposed to two polycationic polymeric nanoparticles, PAMAM dendrimers and MSI-78. We find that regions of the bilayer that are in the gel phase are unaffected by the presence of polymers, whereas the liquid phase is disrupted.

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页码：8588 / 8590

页数：3

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