Protective and pathogenic functions of macrophage subsets

被引：3944

作者：

Murray, Peter J. ^{[1
,2
]}

Wynn, Thomas A. ^{[3
,4
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

[3] NIAID, Program Barrier Immun & Repair, Bethesda, MD 20892 USA

[4] NIAID, Immunopathogenesis Sect, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 11期

基金：

美国国家卫生研究院;

关键词：

ALTERNATIVELY ACTIVATED MACROPHAGES; REGULATORY T-CELLS; TUMOR-ASSOCIATED MACROPHAGES; SUBCAPSULAR SINUS MACROPHAGES; DENDRITIC CELLS; BONE-MARROW; ANTIINFLAMMATORY MACROPHAGES; INTESTINAL MACROPHAGES; INFLAMMATORY MONOCYTES; CYTOKINE PRODUCTION;

D O I：

10.1038/nri3073

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Macrophages are strategically located throughout the body tissues, where they ingest and process foreign materials, dead cells and debris and recruit additional macrophages in response to inflammatory signals. They are highly heterogeneous cells that can rapidly change their function in response to local microenvironmental signals. In this Review, we discuss the four stages of orderly inflammation mediated by macrophages: recruitment to tissues; differentiation and activation in situ; conversion to suppressive cells; and restoration of tissue homeostasis. We also discuss the protective and pathogenic functions of the various macrophage subsets in antimicrobial defence, antitumour immune responses, metabolism and obesity, allergy and asthma, tumorigenesis, autoimmunity, atherosclerosis, fibrosis and wound healing. Finally, we briefly discuss the characterization of macrophage heterogeneity in humans.

引用

收藏

页码：723 / 737

页数：15

相关论文

共 176 条

[1] Identification of scavenger receptor SR-BI as a high density lipoprotein receptor [J].

Acton, S ;

Rigotti, A ;

Landschulz, KT ;

Xu, SZ ;

Hobbs, HH ;

Krieger, M .

SCIENCE, 1996, 271 (5248) :518-520

[2] Inhibition of Mac-1 (CD11b/CD18) enhances tumor response to radiation by reducing myeloid cell recruitment [J].

Ahn, G-One ;

Tseng, Diane ;

Liao, Cho-Hwa ;

Dorie, Mary Jo ;

Czechowicz, Agnieszka ;

Brown, J. Martin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (18) :8363-8368

[3] TNF/iNOS-producing dendritic cells are the necessary evil of lethal influenza virus infection [J].

Aldridge, Jerry R., Jr. ;

Moseley, Carson E. ;

Boltz, David A. ;

Negovetich, Nicholas J. ;

Reynolds, Cory ;

Franks, John ;

Brown, Scott A. ;

Doherty, Peter C. ;

Webster, Robert G. ;

Thomas, Paul G. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (13) :5306-5311

[4] FcRγ Activation Regulates Inflammation-Associated Squamous Carcinogenesis [J].

Andreu, Pauline ;

Johansson, Magnus ;

Affara, Nesrine I. ;

Pucci, Ferdinando ;

Tan, Tingting ;

Junankar, Simon ;

Korets, Lidiya ;

Lam, Julia ;

Tawfik, David ;

DeNardo, David G. ;

Naldini, Luigi ;

de Visser, Karin E. ;

De Palma, Michele ;

Coussens, Lisa M. .

CANCER CELL, 2010, 17 (02) :121-134

[5] Memory TH2 cells induce alternatively activated macrophages to mediate protection against nematode parasites [J].

Anthony, Robert M. ;

Urban, Joseph F., Jr. ;

Alem, Farhang ;

Hamed, Hossein A. ;

Rozo, Cristina T. ;

Boucher, Jean-Luc ;

Van Rooijen, Nico ;

Gause, William C. .

NATURE MEDICINE, 2006, 12 (08) :955-960

[6] Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation [J].

Aouadi, Myriam ;

Tesz, Gregory J. ;

Nicoloro, Sarah M. ;

Wang, Mengxi ;

Chouinard, My ;

Soto, Ernesto ;

Ostroff, Gary R. ;

Czech, Michael P. .

NATURE, 2009, 458 (7242) :1180-U116

[7] Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis [J].

Arnold, Ludovic ;

Henry, Adeline ;

Poron, Francoise ;

Baba-Amer, Yasmine ;

van Rooijen, Nico ;

Plonquet, Anne ;

Gherardi, Romain K. ;

Chazaud, Benedicte .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (05) :1057-1069

[8] CD169-Positive Macrophages Dominate Antitumor Immunity by Crosspresenting Dead Cell-Associated Antigens [J].

Asano, Kenichi ;

Nabeyama, Ami ;

Miyake, Yasunobu ;

Qiu, Chun-Hong ;

Kurita, Ai ;

Tomura, Michio ;

Kanagawa, Osami ;

Fujii, Shin-ichiro ;

Tanaka, Masato .

IMMUNITY, 2011, 34 (01) :85-95

[9] Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages [J].

Atabai, Kamran ;

Jame, Sina ;

Azhar, Nabil ;

Kuo, Alex ;

Lam, Michael ;

McKleroy, William ;

DeHart, Greg ;

Rahman, Salman ;

Xia, Dee Dee ;

Melton, Andrew C. ;

Wolters, Paul ;

Emson, Claire L. ;

Turner, Scott M. ;

Werb, Zena ;

Sheppard, Dean .

JOURNAL OF CLINICAL INVESTIGATION, 2009, 119 (12) :3713-3722

[10] MafB/c-Maf Deficiency Enables Self-Renewal of Differentiated Functional Macrophages [J].

Aziz, Athar ;

Soucie, Erinn ;

Sarrazin, Sandrine ;

Sieweke, Michael H. .

SCIENCE, 2009, 326 (5954) :867-871

← 1 2 3 4 5 6 7 8 9 10 →