In vitro and in vivo toxicity of magnetic microspheres

被引：121

作者：

Häfeli, UO ^{[1
]}

Pauer, GJ ^{[1
]}

机构：

[1] Cleveland Clin Fdn, Radiat Oncol Dept T29, Cleveland, OH 44195 USA

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 1999年 / 194卷 / 1-3期

关键词：

toxicity; magnetic microspheres; polymer; poly(lactic acid); MTT assay; rat; intrathecal;

D O I：

10.1016/S0304-8853(98)00560-5

中图分类号：

T [工业技术];

学科分类号：

08 [工学];

摘要：

The interaction of magnetic microspheres with cells was studied using an in vitro 3-[4,5-dimethylthiazol-2yl]-2,5-diphenyltetrazolium bromide (= MTT) assay. Viability and metabolic activity were reduced in all examples. The MTT assay is not recommended for this application due to high variability and non-specificity. Poly(lactic acid) microspheres were further tested in vivo. Intrathecal injection in rats produced no obvious side effects: over 12 months. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：76 / 82

页数：7

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