Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis

被引：100

作者：

Geddes, BJ ^{[1
]}

Wang, L ^{[1
]}

Huang, WJ ^{[1
]}

Lavellee, M ^{[1
]}

Manji, GA ^{[1
]}

Brown, M ^{[1
]}

Jurman, M ^{[1
]}

Cao, J ^{[1
]}

Morgenstern, J ^{[1
]}

Merriam, S ^{[1
]}

Glucksmann, MA ^{[1
]}

DiStefano, PS ^{[1
]}

Bertin, J ^{[1
]}

机构：

[1] Millennium Pharmaceut Inc, Cambridge, MA 02139 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2001年 / 284卷 / 01期

关键词：

CARD12; protein; CARD domain; nucleotide-binding site; leucine-rich repeats; apoptosis; CED4/Apaf-1 family member; caspase-1; ASC;

D O I：

10.1006/bbrc.2001.4928

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The CED4/Apaf-1 family of proteins functions as critical regulators of apoptosis and NF-KB signaling pathways. A novel human member of this family, called CARD12, was identified that induces apoptosis when expressed in cells. CARD12 is most similar in structure to the CED4/Apaf-1 family member CARD4, and is comprised of an N-terminal caspase recruitment domain (CARD), a central nucleotide-binding site (NBS),;md a C-terminal domain of leucine-rich repeats (LRR). The CARD domain of CARD12 interacts selectively with the CARD domain of ASC, a recently identified pro-apoptotic protein. In addition, CARD12 coprecipitates caspase-1, a caspase that participates in both apoptotic signaling and cytokine processing. CARD12 may assemble with proapoptotic CARD proteins to coordinate the activation of downstream apoptotic and inflammatory signaling pathways. (C) 2001 Academic Press.

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收藏

页码：77 / 82

页数：6

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