gp96-peptide vaccination of mice against intracellular bacteria

被引：43

作者：

Zügel, U

Sponaas, AM

Neckermann, J

Schoel, B

Kaufmann, SHE

机构：

[1] Max Planck Inst Infect Biol, D-10117 Berlin, Germany

[2] Univ Ulm, Dept Immunol, D-89070 Ulm, Germany

来源：

INFECTION AND IMMUNITY | 2001年 / 69卷 / 06期

关键词：

D O I：

10.1128/IAI.69.6.4164-4167.2001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and confer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria. Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens.

引用

页码：4164 / 4167

页数：4

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