Cholesterol in islet dysfunction and type 2 diabetes

被引：136

作者：

Brunham, Liam R. ^{[1
]}

Kruit, Janine K. ^{[1
]}

Verchere, C. Bruce ^{[2
,3
]}

Hayden, Michael R. ^{[1
]}

机构：

[1] Univ British Columbia, Ctr Mol Med & Therapeut, Child & Family Res Inst, Dept Med Genet, Vancouver, BC V5Z 4H4, Canada

[2] Univ British Columbia, Ctr Mol Med & Therapeut, Child & Family Res Inst, Dept Pathol, Vancouver, BC V5Z 4H4, Canada

[3] Univ British Columbia, Ctr Mol Med & Therapeut, Child & Family Res Inst, Lab Med, Vancouver, BC V5Z 4H4, Canada

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2008年 / 118卷 / 02期

关键词：

D O I：

10.1172/JCI33296

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Type 2 diabetes (T2D) frequently occurs in the context of abnormalities of plasma lipoproteins. However, a role for elevated levels of plasma cholesterol in the pathogenesis of this disease is not well established. Recent evidence suggests that alterations of plasma and islet cholesterol levels may contribute to islet dysfunction and loss of insulin secretion. A number of genes involved in lipid metabolism have been implicated in T2D. Recently an important role for ABCA1, a cellular cholesterol transporter, has emerged in regulating cholesterol homeostasis and insulin secretion in pancreatic beta cells. Here we review the impact of cholesterol metabolism on islet function and its potential relationship to T2D.

引用

页码：403 / 408

页数：6

共 82 条

[1] Human high-density lipoprotein particles prevent activation of the JNK pathway induced by human oxidised low-density lipoprotein particles in pancreatic beta cells [J].

Abderrahmani, A. ;

Niederhauser, G. ;

Favre, D. ;

Abdelli, S. ;

Ferdaoussi, M. ;

Yang, J. Y. ;

Regazzi, R. ;

Widmann, C. ;

Waeber, G. .

DIABETOLOGIA, 2007, 50 (06) :1304-1314

[2] Leukocyte ABCA1 gene expression is associated with fasting glucose concentration in normoglycemic men [J].

Albrecht, C ;

Simon-Vermot, I ;

Elliott, JI ;

Higgins, CF ;

Johnston, DG ;

Valabhji, J .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (01) :17-21

[3] Stearoyl-CoA desaturase deficiency, hypercholesterolemia, cholestasis, and diabetes [J].

Attie, Alan D. ;

Flowers, Matthew T. ;

Flowers, Jessica B. ;

Groen, Albert K. ;

Kuipers, Folkert ;

Ntambi, James M. .

NUTRITION REVIEWS, 2007, 65 (06) :S35-S38

[4] The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease [J].

Bodzioch, M ;

Orsó, E ;

Klucken, T ;

Langmann, T ;

Böttcher, L ;

Diederich, W ;

Drobnik, W ;

Barlage, S ;

Büchler, C ;

Porsch-Özcürümez, M ;

Kaminski, WE ;

Hahmann, HW ;

Oette, K ;

Rothe, G ;

Aslanidis, C ;

Lackner, KJ ;

Schmitz, G .

NATURE GENETICS, 1999, 22 (04) :347-351

[5] Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency [J].

Brooks-Wilson, A ;

Marcil, M ;

Clee, SM ;

Zhang, LH ;

Roomp, K ;

van Dam, M ;

Yu, L ;

Brewer, C ;

Collins, JA ;

Molhuizen, HOF ;

Loubser, O ;

Ouelette, BFF ;

Fichter, K ;

Ashbourne-Excoffon, KJD ;

Sensen, CW ;

Scherer, S ;

Mott, S ;

Denis, M ;

Martindale, D ;

Frohlich, J ;

Morgan, K ;

Koop, B ;

Pimstone, S ;

Kastelein, JJP ;

Genest, J ;

Hayden, MR .

NATURE GENETICS, 1999, 22 (04) :336-345

[6] A RECEPTOR-MEDIATED PATHWAY FOR CHOLESTEROL HOMEOSTASIS [J].

BROWN, MS ;

GOLDSTEIN, JL .

SCIENCE, 1986, 232 (4746) :34-47

[7] β-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment [J].

Brunham, Liam R. ;

Kruit, Janine K. ;

Pape, Terry D. ;

Timmins, Jenelle M. ;

Reuwer, Anne Q. ;

Vasanji, Zainisha ;

Marsh, Brad J. ;

Rodrigues, Brian ;

Johnson, James D. ;

Parks, John S. ;

Verchere, C. Bruce ;

Hayden, Michael R. .

NATURE MEDICINE, 2007, 13 (03) :340-347

[8] Variations on a gene:: Rare and common variants in ABCA1 and their impact on HDL cholesterol levels and atherosclerosis [J].

Brunham, Liam R. ;

Singaraja, Roshni R. ;

Hayden, Michael R. .

ANNUAL REVIEW OF NUTRITION, 2006, 26 :105-129

[9] Accurate prediction of the functional significance of single nucleotide polymorphisms and mutations in the ABCA1 gene [J].

Brunham, LR ;

Singaraja, RR ;

Pape, TD ;

Kejariwal, A ;

Thomas, PD ;

Hayden, MR .

PLOS GENETICS, 2005, 1 (06) :739-747

[10] Intestinal ABCA1 directly contributes to HDL biogenesis in vivo [J].

Brunham, LR ;

Kruit, JK ;

Iqbal, J ;

Fievet, C ;

Timmins, JM ;

Pape, TD ;

Coburn, BA ;

Bissada, N ;

Staels, B ;

Groen, AK ;

Hussain, MM ;

Parks, JS ;

Kuipers, F ;

Hayden, MR .

JOURNAL OF CLINICAL INVESTIGATION, 2006, 116 (04) :1052-1062

← 1 2 3 4 5 6 7 8 9 →