Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific γδ T Cell Compartments

被引：280

作者：

Barros, Rafael Di Marco ^{[1
,2
,3
]}

Roberts, Natalie A. ^{[1
]}

Dart, Robin J. ^{[1
,2
,4
]}

Vantourout, Pierre ^{[2
]}

Jandke, Anett ^{[1
]}

Nussbaumer, Oliver ^{[2
]}

Deban, Livija ^{[1
]}

Cipolat, Sara ^{[1
]}

Hart, Rosie ^{[1
]}

Iannitto, Maria Luisa ^{[2
]}

Laing, Adam ^{[2
]}

Spencer-Dene, Bradley ^{[1
]}

East, Philip ^{[1
]}

Gibbons, Deena ^{[2
]}

Irving, Peter M. ^{[4
]}

Pereira, Pablo ^{[5
]}

Steinhoff, Ulrich ^{[6
,7
]}

Hayday, Adrian ^{[1
,2
]}

机构：

[1] Francis Crick Inst, London WC2A3LY, England

[2] Kings Coll London, Peter Gorer Dept Immunobiol, London SE1 9RT, England

[3] UCL, MBPhD Programme, London WC1E 6BT, England

[4] Guys & St Thomas Fdn Trust, Dept Gastroenterol, London SE1 7EH, England

[5] Inst Pasteur, Dept Immunol, F-75015 Paris, France

[6] Univ Marburg, Inst Med Microbiol, D-35037 Marburg, Germany

[7] Univ Marburg, Hosp Epidemiol, D-35037 Marburg, Germany

来源：

CELL | 2016年 / 167卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

MAJOR HISTOCOMPATIBILITY COMPLEX; CLASS-II; GENE FAMILY; MILK-FAT; EXPRESSION; ANTIGEN; LYMPHOCYTES; EVOLUTION; SELECTION; SKINT-1;

D O I：

10.1016/j.cell.2016.08.030

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Many body surfaces harbor organ-specific gamma delta T cell compartments that contribute to tissue integrity. Thus, murine dendritic epidermal T cells (DETCs) uniquely expressing T cell receptor (TCR)-V gamma 5 chains protect from cutaneous carcinogens. The DETC repertoire is shaped by Skint1, a butyrophilin-like (Btnl) gene expressed specifically by thymic epithelial cells and suprabasal keratinocytes. However, the generality of this mechanism has remained opaque, since neither Skint1 nor DETCs are evolutionarily conserved. Here, Btnl1 expressed by murine enterocytes is shown to shape the local TCR-V gamma 7(+) gamma delta compartment. Uninfluenced by microbial or food antigens, this activity evokes the developmental selection of TCR alpha beta(+) repertoires. Indeed, Btnl1 and Btnl6 jointly induce TCR-dependent responses specifically in intestinal V gamma 7(+) cells. Likewise, human gut epithelial cells express BTNL3 and BTNL8 that jointly induce selective TCR-dependent responses of human colonic V gamma 4(+) cells. Hence, a conserved mechanism emerges whereby epithelia use organ-specific BTNL/Btnl genes to shape local T cell compartments.

引用

页码：203 / +

页数：33

共 74 条

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