The inhibition of low density lipoprotein oxidation by 17-alpha estradiol

被引：5

作者：

Dittrich, R

Müller, A

Hensen, J

Wildt, L

机构：

[1] Univ Erlangen Nurnberg, Dept Obstet & Gynaecol, Div Gynaecol Endocrinol & Reprod Med, D-91054 Erlangen, Germany

[2] Univ Erlangen Nurnberg, Dept Med 1, Div Endocrinol, D-8520 Erlangen, Germany

来源：

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES | 1999年 / 107卷 / 01期

关键词：

LDL oxidation; 17-alpha estradiol; antioxidants; atherosclerosis;

D O I：

10.1055/s-0029-1212073

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The inhibition of LDL-oxidation by 17-alpha estradiol was assessed in vitro by the determination of the duration of the lag-phase in copper ion-induced oxidation and compared to that of 17-beta estradiol, estriol, and probucol. Addition of 0.2, 0.4, and 1 mu mol/l of the test substances prolonged the lag-phase of LDL-oxidation 1.3-(+/-0.09 SD), 1.7-(+/-0.14 SD), and 2.7-(+/-0.25 SD) fold for 17-alpha estradiol; 1.4-(+/-0.14 SD), 1.8-(+/-0.1 SD), and 2.6-(+/-0.16 SD) fold for 17-beta estradiol; 1.1-(+/-0.07 SD), 1.4-(+/-0.11 SD), and 1.6-(+/-0.11 SD) fold for estriol as well as 1.4-(+/-0.14 SD), 1.6-(+/-0.1 SD), and 3.0-(+/-0.21) fold for probucol, thus proving that 17-alpha estradiol is as effective as 17-beta estradiol or similar to probucol and more effective than estriol (n = 6 in all cases). These data demonstrate that 17-alpha estradiol is able to delay LDL-oxidation, hence providing a basis for clinical examination of the protective effects of 17-alpha estradiol against artherosclerosis in patients where hormonal effects of 17-beta estradiol are undesirable.

引用

页码：53 / 57

页数：5

共 34 条

[1] OXIDATION OF LOW-DENSITY LIPOPROTEINS - INTRAINDIVIDUAL VARIABILITY AND THE EFFECT OF DIETARY LINOLEATE SUPPLEMENTATION [J].

ABBEY, M ;

BELLING, GB ;

NOAKES, M ;

HIRATA, F ;

NESTEL, PJ .

AMERICAN JOURNAL OF CLINICAL NUTRITION, 1993, 57 (03) :391-398

[2] ORAL-CONTRACEPTIVES, LIPOPROTEINS, AND ATHEROSCLEROSIS [J].

ADAMS, MR ;

CLARKSON, TB ;

SHIVELY, CA ;

PARKS, JS ;

KAPLAN, JR .

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1990, 163 (04) :1388-1393

[3] Estradiol-17 beta as an antioxidant: Some distinct features when compared with common fat-soluble antioxidants [J].

Ayres, S ;

Tang, MY ;

Subbiah, MTR .

JOURNAL OF LABORATORY AND CLINICAL MEDICINE, 1996, 128 (04) :367-375

[4] ENHANCED SUSCEPTIBILITY OF LOW-DENSITY-LIPOPROTEIN TO IN-VITRO OXIDATION IN TYPE-1 AND TYPE-2 DIABETIC-PATIENTS [J].

BEAUDEUX, JL ;

GUILLAUSSEAU, PJ ;

PEYNET, J ;

FLOURIE, F ;

ASSAYAG, M ;

TIELMANS, D ;

WARNET, A ;

ROUSSELET, F .

CLINICA CHIMICA ACTA, 1995, 239 (02) :131-141

[5]

COMINACINI L, 1991, J LIPID RES, V32, P349

[6]

ESTERBAUER H, 1987, J LIPID RES, V28, P495

[7] CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].

ESTERBAUER, H ;

STRIEGL, G ;

PUHL, H ;

ROTHENEDER, M .

FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 6 (01) :67-75

[8]

EZAKI M, 1995, J LIPID RES, V36, P1996

[9] PLASMA OXIDIZABILITY IN SUBJECTS WITH NORMAL GLUCOSE-TOLERANCE, IMPAIRED GLUCOSE-TOLERANCE, AND NIDDM [J].

HAFFNER, SM ;

AGIL, A ;

MYKKANEN, L ;

STERN, MP ;

JIALAL, I .

DIABETES CARE, 1995, 18 (05) :646-653

[10] Increased oxidation of LDL in patients with coronary artery disease is independent from dietary vitamins E and C [J].

Halevy, D ;

Thiery, J ;

Nagel, D ;

Arnold, S ;

Erdmann, E ;

Hofling, B ;

Cremer, P ;

Seidel, D .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1997, 17 (07) :1432-1437

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