Strong Correlation between Liver and Serum Levels of Hepatitis C Virus Core Antigen and RNA in Chronically Infected Patients

被引：28

作者：

Descamps, V. ^{[1
,2
]}

de Beeck, A. Op ^{[3
]}

Plassart, C. ^{[1
,2
]}

Brochot, E. ^{[1
,2
]}

Francois, C. ^{[1
,2
]}

Helle, F. ^{[2
]}

Adler, M. ^{[4
]}

Bourgeois, N. ^{[4
]}

Degre, D. ^{[4
,5
]}

Duverlie, G. ^{[1
,2
]}

Castelaina, S. ^{[1
,2
]}

机构：

[1] Amiens Univ Hosp, South Hosp, Dept Virol, Amiens, France

[2] Jules Verne Univ Picardy, Amiens, France

[3] Univ Libre Bruxelles, Fac Med, Mol Virol Lab, Brussels, Belgium

[4] Univ Libre Bruxelles, Erasme Hosp, Dept Gastroenterol Hepatopancreatol & Digest Onco, Brussels, Belgium

[5] Univ Libre Bruxelles, Lab Expt Gastroenterol, Brussels, Belgium

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 02期

关键词：

CLINICAL UTILITY; QUANTITATIVE-DETERMINATION; QUANTIFICATION; HCV; ASSAY; REPLICATION; PERFORMANCE; THERAPY; PCR;

D O I：

10.1128/JCM.06503-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

HCV core antigen (Ag) and HCV RNA levels were evaluated in matched liver biopsy samples and sera from 22 patients with hepatitis C infection by using the quantitative Architect HCV Ag immunoassay and a real-time RT-qPCR assay, respectively. The data showed a strong correlation between liver and serum compartments of HCV Ag levels (r = 0.80) and HCV RNA levels (r = 0.87). In summary, the serum HCV Ag and RNA levels reflect the intrahepatic values.

引用

页码：465 / 468

页数：4

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