Bone resorption inhibitors from hop extract

被引：99

作者：

Tobe, H ^{[1
]}

Muraki, Y ^{[1
]}

Kitamura, K ^{[1
]}

Komiyama, O ^{[1
]}

Sato, Y ^{[1
]}

Sugioka, T ^{[1
]}

Maruyama, HB ^{[1
]}

Matsuda, E ^{[1
]}

Nagai, M ^{[1
]}

机构：

[1] HOSHI UNIV, FAC PHARMACEUT SCI, SHINAGAWA KU, TOKYO 142, JAPAN

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 01期

关键词：

bone resorption inhibitor; hop extract; humulone; xanthohumol;

D O I：

10.1271/bbb.61.158

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients, Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9) M.

引用

页码：158 / 159

页数：2

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