The flamingo-related mouse Celsr family (Celsr1-3) genes exhibit distinct patterns of expression during embryonic development

被引：73

作者：

Formstone, CJ ^{[1
]}

Little, PFR ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Biochem, London SW7 2AZ, England

来源：

MECHANISMS OF DEVELOPMENT | 2001年 / 109卷 / 01期

基金：

英国惠康基金;

关键词：

seven-pass transmembrane; cadherin; Celsr; flamingo; planar cell polarity; gastrulation; hindbrain; spinal cord; peripheral nervous system;

D O I：

10.1016/S0925-4773(01)00515-9

中图分类号：

Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学];

摘要：

We have isolated cDNAs for three members of a family of seven-pass transmembrane cadherins in mouse (Celsr1, 2 and 3). These three genes represent vertebrate homologues of flamingo/starry night, recently identified as an essential component of the Drosophila planar cell polarity pathway and for the correct formation of dendritic fields within the Drosophila peripheral nervous system. In this study, we show that each member of the mouse Celsr family exhibit distinct patterns of expression within a range of different tissues within the developing embryo. Celsr1 and Celsr2 expression is observed during gastrulation and within the developing nervous system. Celsr3 transcripts, however, are found only at sites of active neurogenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：91 / 94

页数：4

共 15 条

[1]

Frizzled proteins constitute a novel family of G protein-coupled receptors, most closely related to the secretin family [J].

Barnes, MR ;

Duckworth, DM ;

Beeley, LJ .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1998, 19 (10) :399-400

[2]

Chae J, 1999, DEVELOPMENT, V126, P5421

[3]

RNA-RNA IN-SITU HYBRIDIZATION USING DIGOXIGENIN-LABELED PROBES - THE USE OF HIGH-MOLECULAR-WEIGHT POLYVINYL-ALCOHOL IN THE ALKALINE-PHOSPHATASE INDOXYL-NITROBLUE TETRAZOLIUM REACTION [J].

DEBLOCK, M ;

DEBROUWER, D .

ANALYTICAL BIOCHEMISTRY, 1993, 215 (01) :86-89

[4]

Chromosomal localization of Celsr2 and Celsr3 in the mouse;: Celsr3 is a candidate for the tippy (tip) lethal mutant on Chromosome 9 [J].

Formstone, CJ ;

Barclay, J ;

Rees, M ;

Little, PFR .

MAMMALIAN GENOME, 2000, 11 (05) :392-394

[5]

Genes regulating dendritic outgrowth, branching, and routing in Drosophila [J].

Gao, FB ;

Brenman, JE ;

Jan, LY ;

Jan, YN .

GENES & DEVELOPMENT, 1999, 13 (19) :2549-2561

[6]

Control of dendritic field formation in Drosophila:: The roles of flamingo and competition between homologous neurons [J].

Gao, FB ;

Kohwi, M ;

Brenman, JE ;

Jan, LY ;

Jan, YN .

NEURON, 2000, 28 (01) :91-101

[7]

Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter [J].

Hadjantonakis, AK ;

Sheward, WJ ;

Harmar, AJ ;

deGalan, L ;

Hoovers, JMN ;

Little, PFR .

GENOMICS, 1997, 45 (01) :97-104

[8]

MCelsrl is an evolutionarily conserved seven-pass transmembrane receptor and is expressed during mouse embryonic development [J].

Hadjantonakis, AK ;

Formstone, CJ ;

Little, PFR .

MECHANISMS OF DEVELOPMENT, 1998, 78 (1-2) :91-95

[9]

EXPRESSION OF A DELTA-HOMOLOG IN PROSPECTIVE NEURONS IN THE CHICK [J].

HENRIQUE, D ;

ADAM, J ;

MYAT, A ;

CHITNIS, A ;

LEWIS, J ;

ISHHOROWICZ, D .

NATURE, 1995, 375 (6534) :787-790

[10]

Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening [J].

Nakayama, M ;

Nakajima, D ;

Nagase, T ;

Nomura, N ;

Seki, N ;

Ohara, O .

GENOMICS, 1998, 51 (01) :27-34

← 1 2 →